Publications by authors named "K Koscinska"
Aging is an exceptionally complex process that depends on genetic, environmental, and lifestyle factors. Previous studies within the International HLA and Immunogenetics Workshop (IHIWS) component "Immunogenetics of Ageing" showed that longevity is associated with positive selection of HLA-DRB1*11- and DRB1*16-associated haplotypes, shown to be protective against diseases. Within the 18th IHIWS, we aimed to investigate the relevance of telomere length for successful aging and its association with classical HLAs.
View Article and Find Full Text PDFBackground: Deep tissue massage (DTM), based on deep palpation and elimination of fascia restrictions, can reduce symptoms resulting from fascial disorders. The goal of this study was the analysis of the DTM effect on respiratory parameters in healthy people.
Material And Methods: The study involved a group of 40 people divided into two subgroups.
The present study aimed to analyse and compare the distribution of MICA (rs1051792) and NKG2D/KLRK1 (rs1154831, rs1049174, rs2255336) polymorphisms in 61 Greek and 100 Polish patients with rheumatoid arthritis in relation to the presence of the HLA-DRB1 shared epitope and clinical parameters. Genotyping of selected polymorphism was performed using real-time PCR. HLA-DRB1 shared epitope alleles segregated differently in Greek and Polish patients but in both populations were detected in over 60% of cases.
View Article and Find Full Text PDFHLA-inferred extended haplotype disparity level is more relevant than the level of HLA mismatch alone for the patients survival and GvHD in T cell-replate hematopoietic stem cell transplantation from unrelated donor.
Hum Immunol
June 2018
Article Synopsis
- Unrelated hematopoietic stem cell transplantation (HSCT) poses serious risks like graft versus host disease (GvHD) and mortality, which are heightened by differences in HLA (human leukocyte antigen) between donors and recipients.
- A study involving 889 patients revealed that higher levels of Ehp (extended MHC haplotype) mismatch lead to increased incidences of GvHD and mortality, independent of the HLA mismatch level.
- Patients with a single HLA mismatch but double Ehp disparity showed significantly lower overall survival rates and higher non-relapse mortality compared to those with only one Ehp mismatch, suggesting that Ehp matching is crucial in HSCT outcomes.
Natural killer (NK) cell licensing status depends on clonal expression of inhibitory killer cell immunoglobulin-like receptors (iKIR) and short term HLA environment. Licensed NK cells are more efficient in tumor killing than unlicensed NK cells. Cognate KIR-HLA pairs in hematopoietic stem cell transplant (HSCT) donor and recipient are decisive for the possible change in the NK cell licensing status after HSCT.
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