Publications by authors named "K Korpela"
The human gut microbiota is central in regulating all facets of host physiology, and in early life it is thought to influence the host's immune system and metabolism, affecting long-term health. However, longitudinally monitored cohorts with parallel analysis of faecal samples and health data are scarce. In our observational study we describe the gut microbiota development in the first 2 years of life and create a gut microbiota wellbeing index based on the microbiota development and health data in a cohort of nearly 1000 infants using clustering and trajectory modelling.
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- * Involving 709 employees, the research utilized various wellness surveys to correlate psychosocial factors with indicators of occupational health, leading to the identification of critical screening questions.
- * Findings revealed that while most participants felt capable at work, significant proportions reported risks of anxiety, depression, and burnout, pointing to the inadequacy of existing measures and the necessity for a more effective screening tool.
Objectives: Occupational health challenges are changing, emphasising the need for a more comprehensive approach. This study examines how a subjective well-being assessment can be used to identify target groups for work well-being interventions and brings insight into how survey-based well-being evaluations are linked to clinical health indicators (ie, anthropometric measurements and blood tests).
Design: A cross-sectional survey study using results from the Virta1 randomised controlled trial and a third-party well-being questionnaire database.
Microbial colonization of the neonatal gut involves maternal seeding, which is partially disrupted in cesarean-born infants and after intrapartum antibiotic prophylaxis. However, other physically close individuals could complement such seeding. To assess the role of both parents and of induced seeding, we analyzed two longitudinal metagenomic datasets (health and early life microbiota [HELMi]: N = 74 infants, 398 samples, and SECFLOR: N = 7 infants, 35 samples) with cesarean-born infants who received maternal fecal microbiota transplantation (FMT).
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- This study investigated the defecation patterns of 1052 healthy infants up to 17 weeks old, focusing on factors like stool frequency and color.
- The findings showed that breastfed infants had more frequent bowel movements, with a peak frequency at 3 weeks, and a significant portion had green stools without indicating health issues.
- Understanding these patterns helps healthcare providers better identify what is normal in infant bowel habits, clarifying misconceptions about stool color and frequency related to feeding methods.