Assessing the Relationship of Brain Metabolites to Cortical Thickness and Dementia Symptoms in Adults with Down Syndrome: A Pilot Study.

Background/objectives: Those with the genetic disorder Down syndrome are at high risk of developing Alzheimer's disease. Previous work shows group differences in magnetic resonance spectroscopy metabolite measures in adults with Down syndrome who have Alzheimer's disease-related dementia compared to those who do not. In this pilot study, we assess relationships between metabolites and measures related to dementia status in a sample of adults with Down syndrome.

tet2 and tet3 regulate cell fate specification and differentiation events during retinal development.

Tet enzymes are epigenetic modifiers that impact gene expression via 5mC to 5hmC oxidation. Previous work demonstrated the requirement for Tet and 5hmC during zebrafish retinogenesis. mutants possessed defects in the formation of differentiated retinal neurons, but the mechanisms underlying these defects are unknown.

Development of a Brief, Positively Framed Care Team Experience Measure.

Background: Measures that quantify clinician fulfillment and engagement with work (clinician experience measures) have the potential to improve the quality, effectiveness, and enjoyment of patient care. Many existing measures of clinician fulfillment and engagement with work are relatively long and potentially burdensome, negatively framed, or address personal well-being. A measure with a small number of items that address positive attributes to which a team aspires may be a more useful measure to guide organizational improvement efforts.

2024 Mpox outbreak: A rapidly evolving public health emergency of international concern: Introduction of an Updated Mpox Identify-Isolate-Inform (3I) Tool.

The declaration of a second Public Health Emergency of International Concern (PHEIC) for mpox in August 2024 underscores the urgent need for a comprehensive understanding of the evolving epidemiology [1] clinical manifestations, and zoonotic potential of this emerging threat [2]. This work delves into the intricate interplay between human and animal mpox infections, with a specific focus on the unique characteristics of various viral clades and their implications for individual and public health. There is a critical need to elucidate the factors driving multiple spillover events and the subsequent emergence of new clades better adapted to human-to-human transmission.

‎The association between cumulative exposure to neighborhood walkability (NW) and diabetes risk, a prospective cohort study.

Purpose: To examine the association between cumulative exposure to neighborhood walkability (NW) and diabetes risk.

Methods: A total of 11,037 women free of diabetes at enrollment were included. We constructed a 4-item NW index at baseline, and a 2-item average annual NW across years of follow-up that captured both changes in neighborhood features and residential moves.