Publications by authors named "K Kodera"
Article Synopsis
- Histone lactylation is a new epigenetic modification driven by lactate from glycolysis, which is often heightened in cancer, notably gastric cancer (GC), and is linked to poorer patient outcomes.
- In GC, increased levels of histone H3K18 lactylation correlate with worse prognosis, while SIRT1 plays a key role in regulating these levels by either promoting or diminishing H3K18la depending on its expression.
- Targeting the interplay between SIRT1, the lncRNA H19, and glycolysis presents a promising therapeutic approach for GC, showing significant anti-cancer effects while minimizing harm to normal cells.
Background: The aim of this study was to investigate the prognostic value of systematic inflammatory response in patients with lymph node-negative colorectal cancer.
Methods: We retrospectively investigated 245 patients with lymph node-negative colorectal cancer who underwent curative resection and evaluated the prognostic impact of systematic inflammatory response, which was represented by neutrophil-to-lymphocyte ratio (NLR), prognostic nutritional index (PNI), and C-reactive protein-to-albumin ratio (CAR). Then, the prognostic significance of the systematic inflammatory response on survival was analyzed using the Kaplan-Meier method in patients selected by propensity score matching (PSM) analysis.
GPATCH4 contributes to nucleolus morphology and its dysfunction impairs cell viability.
Biochem Biophys Res Commun
January 2024
The nucleolus serves a multifaceted role encompassing not only rRNA transcription and ribosome synthesis, but also the intricate orchestration of cell cycle regulation and the modulation of cellular senescence. G-patch domain containing 4 (GPATCH4) stands as one among the nucleolar proteins; however, its functional significances remain still unclear. In order to elucidate the functions of GPATCH4, we examined the effects of its dysfunction on cellular proliferation, alterations in nucleolar architecture, apoptotic events, and cellular senescence.
View Article and Find Full Text PDFAim: Osteopenia and sarcopenia, features of the aging process, are recognized as major health problems in an aging society. This study investigated the prognostic impact of osteosarcopenia, the coexistence of osteopenia and sarcopenia, in older adults undergoing curative resection for colorectal cancer.
Methods: We retrospectively reviewed data of older adults aged 65-98 y who had undergone curative resection for colorectal cancer.
Article Synopsis
- Incisional hernia is a frequent issue after abdominal surgeries, particularly in obese patients; this study aimed to explore the link between sarcobesity and hernia development following laparoscopic colorectal cancer surgery.
- A total of 262 patients were analyzed, revealing that 16.8% developed incisional hernias, with significant risk factors identified, including female sex, various types of obesity, sarcobesity, and wound infections.
- The findings suggest that sarcobesity is a strong independent predictor of incisional hernia, highlighting the role of body composition in post-surgery complications.