Publications by authors named "K Kocer"
Article Synopsis
- - Cefiderocol is a new antibiotic effective against multidrug-resistant pathogens, showing potential against carbapenem-resistant Pseudomonas aeruginosa (Cr-Pa) infections based on a study of 108 isolates.
- - Out of these isolates, nine displayed resistance with specific mutations linked to iron uptake systems and other resistance-related genes, while no correlation was found between carbapenemases and cefiderocol resistance.
- - The study indicates that while cefiderocol remains a viable treatment option, ongoing research is needed to understand the evolving resistance mechanisms and enhance strategies for managing antimicrobial resistance.
Background: Transmission and outbreaks of carbapenem-resistant Gram-negative bacteria (CRGN) in hospitals are often associated with contamination of the wastewater environment. We performed a prospective observational study to investigate the colonization of the hospital wastewater environment during the first year of occupancy of the surgical intermediate and intensive care units of a newly constructed building at the University Hospital of Heidelberg, Germany.
Methods: We performed monthly screening of the wastewater system (toilets and sinks) for 12 months, starting 1 month before opening (1 October 2020 to 30 October 2021).
Article Synopsis
- Resistance to cefiderocol, a new antibiotic, in E. coli linked to metallo-β-lactamases like NDM-5 and VIM-1, while KPC-2 and OXA-48 do not contribute.
- The study involved transferring β-lactamases into E. coli and testing their ability to develop resistance through serial exposure to cefiderocol.
- Notable changes in the bacterial morphology and the emergence of small-colony variants (SCVs) were observed, potentially affecting how these bacteria evade the immune system and respond to treatment.
Background: Cefiderocol is a novel siderophore cephalosporin active against MDR Gram-negative bacilli, including MBL-harbouring Enterobacterales. The detection of multiple cefiderocol-resistant blaVIM-carrying Enterobacterales isolates (MIC = 4 mg/L) from a single patient suggested an additional, potentially transferable, resistance determinant as blaVIM typically does not elevate cefiderocol MIC above the resistance threshold.
Methods: Transfer of a mobile genetic element was performed in liquid mating experiments.
New Delhi Metallo-Beta-Lactamase Facilitates the Emergence of Cefiderocol Resistance in Enterobacter cloacae.
Antimicrob Agents Chemother
February 2022
Article Synopsis
- Cefiderocol is a new antibiotic that targets multidrug-resistant Gram-negative bacteria and is resistant to certain enzymes that typically break down antibiotics.
- However, there have been instances where bacteria producing metallo-β-lactamases have developed resistance to cefiderocol during treatment.
- Research showed that a specific enzyme (NDM) helps bacteria gain resistance through mutations, but using dipicolinic acid can inhibit these enzymes and reduce the chances of resistance, highlighting the need for caution in treatment choices.