Publications by authors named "K Kober"
Background: Cancer-related cognitive impairment (CRCI) is reported by 45% of patients with cancer. Significant gaps in knowledge remain regarding the mechanisms that underlie CRCI.
Objectives: Using a data-driven approach, the study purpose was to evaluate for perturbed pathways associated with membership in the High versus the Low CRCI profiles.
Introduction: Identifying reliable biomarkers that reflect cancer survivorship symptoms remains a challenge for researchers. DNA methylation (DNAm) measurements reflecting epigenetic changes caused by anti-cancer therapy may provide needed insights. Given lack of consensus describing utilization of DNAm data to predict survivorship issues, a review evaluating the current landscape is warranted.
View Article and Find Full Text PDFObjectives: To identify subgroups of patients with distinct cough occurrence profiles and evaluate for differences among these subgroups.
Sample & Setting: Outpatients receiving chemotherapy (N = 1,338) completed questionnaires six times over two chemotherapy cycles.
Methods & Variables: Occurrence of cough was assessed using the Memorial Symptom Assessment Scale.
Objectives: Evidence suggests that energy is a distinct symptom from fatigue in patients with cancer. The purpose of this paper is to present the Multidimensional Model of Energy in Patients with Cancer (MMEPC) that is based on emerging evidence and to make recommendations for clinical practice and future research.
Methods: The literature was reviewed to determine various factors associated with variations in energy in patients with cancer.
Article Synopsis
- The study investigates the link between cancer-related cognitive impairment (CRCI) and anxiety in cancer patients, aiming to uncover the biological mechanisms behind their co-occurrence.
- Researchers analyzed data from 451 patients undergoing chemotherapy, categorizing them based on levels of CRCI and anxiety, and identified five disrupted neurodegenerative disease pathways.
- Key processes such as apoptosis and oxidative stress were common across these pathways, suggesting potential targets for future therapeutic interventions.