Publications by authors named "K Kobashigawa"

Background & Aims: The efficacy of endoscopic sphincterotomy (ES) before endoscopic transpapillary biliary drainage in preventing post-endoscopic retrograde cholangiopancreatography pancreatitis (PEP) has not been established. The aim of this study was to evaluate the effect of performing ES before biliary stent/tube placement on the occurrence of PEP.

Methods: Three hundred seventy patients with biliary stricture requiring endoscopic biliary stenting were enrolled and randomly allocated to the ES group (n = 185) or non-ES group (n = 185).

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Article Synopsis
  • Aeromonas bacteria, a common pathogen in tropical fish, can lead to serious infections like septicemia, causing high mortality rates in aquaculture, making its study vital for control measures.
  • In an experiment, juvenile pacus were infected with Aeromonas hydrophila, with observations taken at various time points post-infection, showing significant hemodynamic alterations and bacterial presence in tissues by 9 hours.
  • Pathological analyses revealed severe tissue damage, including necrosis and vascular issues, particularly after 6 and 9 hours, suggesting that the bacteria spread rapidly and caused irreversible harm to vital organs like the spleen, liver, and kidney.
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Purposes: To investigate the intra-laboratory reproducibility of clinical features and to evaluate corneal optical anisotropies in a rabbit model of limbal stem cell deficiency.

Methods: Limbal injury was induced in the right eye of 23 adult New Zealand White rabbits using a highly aggressive protocol that combined 360 degrees limbal peritomy, keratolimbectomy, alkaline chemical burn, and mechanical removal of the epithelium. Clinical evaluation of the injured eyes was performed for 28 days and included corneal impression cytology.

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Purpose: To evaluate the effect of metronidazole ophthalmic solutions on corneal neovascularization (CNV) in a rat model.

Methods: A chemical burn was created in the right central cornea of 40 rats. Animals were randomized and distributed into four study groups (n = 10 rats per group) designated Met_0.

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Purpose:: To establish and compare protocols of alkaline cauterization for inducing corneal angiogenesis in murine models.

Methods:: Twenty-four adult Wistar rats were distributed into four groups (G1, G2, G3, and G4). The right eye cornea from each rat was cauterized using filter paper (3 mm), soaked in a solution of silver and potassium nitrates (3:1).

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