Publications by authors named "K Knudsen"
Objective: This trial aimed to compare three low-energy diets (LEDs) with different amounts of carbohydrates (CHO) on ketosis and changes in hunger feelings in adults with obesity.
Methods: A total of 101 adults (51 female) with obesity (BMI, mean [SEM], 34.7 [0.
Article Synopsis
- ASPYRE Technology
- : ASPYRE (Allele-Specific PYrophosphorolysis REaction) was created to provide a quick, affordable, and effective genomic testing method for cancer, specifically non-small cell lung carcinoma, assessing 114 variants in 11 genes simultaneously from tumor samples.
- Testing and Results
- : When tested on various lung tissue samples, ASPYRE-Lung showed a detection sensitivity of ≤ 3% for single nucleotide variants, with perfect specificity and high analytical accuracy, matching expected results without false positives.
- Ease of Use
- : The assay requires minimal steps and standard lab equipment, with data analysis supported by a cloud-based algorithm, making it a potentially transformative tool for
Castration resistant prostate cancer (CRPC) remains an incurable disease stage with ineffective treatments options. Here, the androgen receptor (AR) coactivators CBP/p300, which are histone acetyltransferases, were identified as critical mediators of DNA damage repair (DDR) to potentially enhance therapeutic targeting of CRPC. Key findings demonstrate that CBP/p300 expression increases with disease progression and selects for poor prognosis in metastatic disease.
View Article and Find Full Text PDFIntroduction: The a-Synuclein Origin and Connectome (SOC) model of Lewy body diseases postulates that a-syuclein will be asymmetrically distributed in some patients with Lewy body diseases, potentially leading to asymmetric neuronal dysfunction and symptoms.
Methods: We included two patient groups: 19 non-demented Parkinson's disease (nPD) patients with [F]FDG PET and motor symptoms assessed by UPDRS-III, and 65 Lewy body dementia (LBD) patients with [F]FDG PET and dopamine radioisotope imaging. Asymmetry indices were calculated for [F]FDG PET by including the cortex for each hemisphere, for dopamine radioisotope imaging by including the putamen and caudate separately, and for motor symptoms by using the difference between right-left UPDRS-III score.