Radiation segmentectomy for curative intent of unresectable very early to early stage hepatocellular carcinoma (RASER): a single-centre, single-arm study.

Background: Unresectable solitary very early to early stage hepatocellular carcinoma is managed with ablation for curative intent. Radiation segmentectomy is a treatment option that delivers radioactive yttrium (Y)-bound microspheres transarterially to a segment of liver. The aim of this study was to assess the safety and efficacy of radiation segmentectomy in patients with unresectable hepatocellular carcinoma deemed unfavourable for ablation.

Tumour-to-normal tissue (T/N) dosimetry ratios role in assessment of Y selective internal radiation therapy (SIRT).

Objective: The purpose of our work is to assess the role of tumour-to-normal tissue (T/N) dosimetry ratios for predicting response in patients undergoing locoregional therapy to the liver with Y microspheres.

Methods: A total of 39 patients (7 female:32 male, mean age 68.3 ± 7.

An estimate of Y dosimetry for bremsstrahlung SPECT/CT imaging in liver therapy with Y microspheres.

Objective: Bremsstrahlung SPECT/CT (bSPECT/CT) is one of the most common methods for post-therapy imaging in Y microspheres selective internal radiation therapy (SIRT) of liver cancers. Here, we are proposing a simple approach using bSPECT/CT to estimate mean absorbed dose to the liver in patients undergoing treatment with Y microspheres.

Materials And Methods: In our previous study comparing Y dosimetry obtained using bSPECT/CT vs PET/CT, we found that there was a large difference between the mean absorbed dose values to the whole-liver.

Comparison of posttherapy Y positron emission tomography/computed tomography dosimetry methods in liver therapy with Y microspheres.

The aim of our study was to compare dosimetry methods for yttrium-90 (Y) positron emission tomography/computed tomography (PET/CT). Twenty-five patients were taken to a PET/CT suite following therapy with Y microspheres. The low mA, nondiagnostic CT images were used for attenuation correction and localization of the Y microspheres.

Brain and blood biomarkers of tauopathy and neuronal injury in humans and rats with neurobehavioral syndromes following blast exposure.

Traumatic brain injury (TBI) is a risk factor for the later development of neurodegenerative diseases that may have various underlying pathologies. Chronic traumatic encephalopathy (CTE) in particular is associated with repetitive mild TBI (mTBI) and is characterized pathologically by aggregation of hyperphosphorylated tau into neurofibrillary tangles (NFTs). CTE may be suspected when behavior, cognition, and/or memory deteriorate following repetitive mTBI.