Publications by authors named "K Klose"
() is a major porcine pathogen. Some strains have a substantial zoonotic potential such as serotype () 14 as the second most important in human infections. To this date no licensed vaccine is available in Europe though subunit vaccines and bacterins have been examined by several scientific groups worldwide.
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- Community-based mobile clinics in Miami-Dade County are shown to effectively increase access to pre-exposure prophylaxis (PrEP), particularly for underrepresented groups.
- The study involved over 1,800 clients from fixed and mobile clinics over nearly five years, revealing that mobile clinics successfully reached more cisgender women, Black clients, and older individuals compared to fixed locations.
- Clients using the mobile clinics, especially uninsured and male individuals, demonstrated a higher likelihood of continuing PrEP treatment over 48 weeks, indicating the importance of these services in sustaining care engagement.
The prognosis for children with recurrent and/or refractory neuroblastoma (NB) is dismal. The receptor tyrosine kinase-like orphan receptor 1 (ROR1), which is highly expressed on the surface of NB cells, provides a potential target for novel immunotherapeutics. Anti-ROR1 chimeric antigen receptor engineered expanded peripheral blood natural killer (anti-ROR1 CAR exPBNK) cells represent this approach.
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- Many pathogenic Gram-negative bacteria utilize caretakers, known as repeats-in-toxin adhesins, for adhering and forming biofilms, with FrhA being crucial for cholera.
- Bioinformatic and structural analyses revealed a sugar-binding domain in FrhA, which can recognize fucosylated glycans on human cells, leading to their colonization and lysis.
- The findings suggest that targeting this sugar-binding domain with fucose-based inhibitors could potentially prevent the colonization of pathogenic bacteria, including cholera.
Background: Direct cardiac reprogramming is currently being investigated for the generation of cells with a true cardiomyocyte (CM) phenotype. Based on the original approach of cardiac transcription factor-induced reprogramming of fibroblasts into CM-like cells, various modifications of that strategy have been developed. However, they uniformly suffer from poor reprogramming efficacy and a lack of translational tools for target cell expansion and purification.
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