Publications by authors named "K Kiyota"
SMG9 is an essential component of the nonsense-mediated mRNA decay (NMD) machinery, a quality control mechanism that selectively degrades aberrant transcripts. Mutations in SMG9 are associated with heart and brain malformation syndrome (HBMS). However, the molecular mechanism underlying HBMS remains unclear.
View Article and Find Full Text PDFA previously healthy 22-year-old woman was admitted to our hospital after an out-of-hospital cardiac arrest. Spontaneous circulation was restored prior to arrival at the hospital. However, the patient's vital signs remained unstable.
View Article and Find Full Text PDFV-ATPase is an ATP hydrolysis-driven proton pump involved in the acidification of intracellular organelles and systemic acid-base homeostasis through H secretion in the renal collecting ducts. V-ATPase dysfunction is associated with hereditary distal renal tubular acidosis (dRTA). ATP6V1B1 encodes the B1 subunit of V-ATPase that is integral to ATP hydrolysis and subsequent H transport.
View Article and Find Full Text PDFArticle Synopsis
- In Japan, doctor cars are specialized emergency medical vehicles staffed by physicians, designed to provide advanced trauma care before patients reach the hospital.
- A nationwide study analyzed data from over 372,000 trauma patients to assess the impact of doctor cars compared to non-physician-staffed emergency services on survival rates.
- The results indicate that patients treated by doctor cars have a significantly higher chance of survival in the hospital, suggesting that these units could enhance trauma care strategies in Japan.
Article Synopsis
- P-NMR is easier to analyze than H-NMR, making it simpler to identify target signals for quantitation.
- The study presents a method for determining the purity of brigatinib (BR), an organophosphorus compound, using quantitative P-NMR (P-qNMR) across multiple labs.
- Results showed that the purity of BR was 97.94 ± 0.69% with P-qNMR, closely matching the 97.26 ± 0.71% found using H-qNMR, suggesting P-qNMR is a viable alternative for measuring organophosphorus compounds.