Publications by authors named "K Kitaoka"
Background: Chronic kidney disease (CKD) represents a significant public health challenge, with rates consistently on the rise. Enhancing kidney function prediction could contribute to the early detection, prevention, and management of CKD in clinical practice. We aimed to investigate whether deep learning techniques, especially those suitable for processing missing values, can improve the accuracy of predicting future renal function compared to traditional statistical method, using the Japan Chronic Kidney Disease Database (J-CKD-DB), a nationwide multicenter CKD registry.
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- The study examines the link between oral microbiome diversity and mortality rates from all causes, cardiovascular disease (CVD), and non-CVD, highlighting gaps in knowledge regarding sex and racial/ethnic variations.
- Using data from the National Health and Nutrition Examination Survey (NHANES), researchers analyzed oral rinse samples from 8,199 adults and tracked mortality over about 9 years to assess the impact of microbial diversity on health outcomes.
- Findings indicate that higher oral microbiome diversity is associated with lower mortality rates across groups, particularly among Mexican Americans and Non-Hispanic Whites, but potential mediators like obesity or diabetes did not influence this relationship.
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- T follicular helper (Tfh) cells, which are important for antibody production, rely heavily on the immunoreceptor PD-1, and its deficiency leads to weakened Tfh functions and impaired immune responses in mice.
- Individuals lacking PD-1 or PD-L1 demonstrate fewer memory B cells and diminished antibody responses, highlighting the critical role of these molecules in immune system functionality.
- PD-1 influences both the intrinsic and extrinsic aspects of B cell memory and antibody production, suggesting that disruptions in PD-1 signaling can lead to complications in immune responses, especially during anti-PD-1-PD-L1 therapies.
The association of anemia with hyperadiponectinemia (HAN) (≥ 20 μg/mL) was studied in 95 Japanese women aged 65-74 (young-old), 175 women aged 75-84 (old-old), and 51 women aged over 85 (oldest-old) who resided at home alone without wheelchair use. The prevalence of anemia was 21.5% overall and increased with aging stepwise (9.
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