Publications by authors named "K Kitahama"
Article Synopsis
- Advanced pancreatic ductal adenocarcinoma (PDAC) has different subtypes, with the basal-like subtype showing worse prognosis and chemotherapy resistance compared to the classical subtype.
- This study evaluated immunohistochemistry (IHC) staining of four markers on biopsy samples from 190 untreated advanced PDAC patients, identifying three distinct patterns: Classical, Transitional, and Basal-like.
- The Basal-like pattern was linked to poorer survival rates and associated with specific histological features, making IHC expression patterns a valuable tool for predicting prognosis and guiding treatment decisions in advanced PDAC.
Article Synopsis
- * In a study involving 39 IUP cases, researchers found that 87% had oncogenic mutations in RAS family genes, particularly HRAS, which was linked to smoking and specific morphological traits, while KRAS mutations were only found in non-smokers.
- * The study revealed no cases of recurrence or progression to cancer during follow-up, emphasizing the role of RAS mutations in IUP development and their relationship to different tumor subtypes and spread patterns.
Hepatocellular carcinomas (HCCs) with biliary/progenitor cell features frequently show increased programmed death-ligand 1 (PD-L1) expression, but their response to immunotherapy is not high. One possible explanation for this phenomenon could be the loss of major histocompatibility complex (MHC) class I expression on tumor cells, which impairs the presentation of tumor antigens to cytotoxic T cells. However, the potential correlation between MHC class I loss, biliary/progenitor cell features, and the tumor-immune microenvironment remains largely unexplored.
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