Publications by authors named "K Kingo"
Article Synopsis
- CD4 T cells are essential for adaptive immunity and are linked to autoimmune diseases, but how they malfunction in these diseases is still unclear.
- Researchers used advanced techniques to analyze the active chromatin and gene expression in CD4 T cells from both healthy individuals and those with autoimmune disorders like lupus and arthritis.
- The study identified specific gene regulatory networks affected by enhancers and associated genetic variations, suggesting that changes in CD4 T cell regulation could play a key role in autoimmune disease development and may lead to new treatments.
Electrospun (ES) fibrous nanomaterials have been widely investigated as novel biomaterials. These biomaterials have to be safe and biocompatible; hence, they need to be tested for cytotoxicity before being administered to patients. The aim of this study was to develop a suitable and biorelevant in vitro cytotoxicity assay for ES biomaterials (e.
View Article and Find Full Text PDFIntroduction: Limited real-world evidence exists about the burden of atopic dermatitis (AD) in patients receiving systemic or non-systemic therapies in clinical practices. ESSENTIAL AD was an observational study that aimed to fill this information gap.
Methods: ESSENTIAL AD enrolled (September 2021-June 2022) adult patients with physician-confirmed AD that was routinely managed with systemic and non-systemic treatment in a real-world setting from 15 countries in Eastern Europe, the Middle East, and Africa.
Article Synopsis
- A study was conducted to investigate similarities and differences in protein expressions between psoriasis (PS) and atopic dermatitis (AD), using high-throughput mass spectrometry on skin samples from affected patients and healthy controls.
- The analysis revealed a significant overlap in proteomic profiles of PS and AD, indicating they share common pathogenesis mechanisms, while both differed from healthy skin.
- Notably, periostin (POSTN) was found to be highly expressed in AD but very low or absent in PS, suggesting its potential as a biomarker to distinguish between the two conditions.
Measurements of skin surface biomarkers have enormous value for the detailed assessment of skin conditions, both for clinical application and in skin care. The main goals of the current study were to assess whether expression patterns of skin surface hBD-1, hBD-2, IL-1α, CXCL-1, and CXCL-8, examples of proteins known to be involved in psoriasis pathology, are associated with disease severity and whether expression patterns of these proteins on the skin surface can be used to measure pharmacodynamic effects of biological therapy. In this observational study using transdermal analysis patch (TAP), levels of skin surface IL-1α, hBD-1, hBD-2, CXCL-1/2, and CXCL-8 of psoriasis vulgaris (PV) patients over biological therapy were assessed.
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