Prostaglandin F2alpha-induced Ca++ oscillations in human myometrial cells and the role of RU 486.

Objective: We sought to examine the change of cytosolic calcium concentration caused by prostaglandin F(2)(alpha) and RU 486 in cultured human myometrial cells.

Study Design: Human myometrial cells obtained from 16 nonpregnant women were loaded with fura 2, and the intracellular cytosolic calcium concentrations were measured by the use of wavelength spectrophotofluorometry.

Results: Application of prostaglandin F(2)(alpha) (2.