Publications by authors named "K Kebaili"
Background: This study aims to compare the infections' risk between adolescents and young adults (AYAs), treated for acute lymphoblastic leukemia, and pediatric population. We also focused on their bacterial and fungal infection specificities.
Methods: This case-control study investigated the occurrence of bacterial bloodstream infection (BSI) and proven and probable invasive fungal infection (IFI) in AYAs (15-25 years old) and children (1-14 years old) treated for acute lymphoblastic leukemia between January 2013 and December 2020 in 2 French tertiary pediatric and 2 referral adult hematological centers, independent of their treatment protocol.
Red blood cell exchanges are frequently used to treat and prevent cerebrovascular complications in patients with sickle cell anemia (SCA). However, the low weight of young children represents serious concerns for this procedure. The Spectra Optia device can perform automatic priming using red blood cells (RBCs) (RCE/RBC-primed) which could allow RBC exchanges (RCE) to be performed in young children without hypovolemic complications, but this method requires evaluation.
View Article and Find Full Text PDFThe present study tested the impact of α-thalassaemia on oxygen gradient ektacytometry in sickle cell anaemia (SCA). Three SCA groups were compared: (i) no α-thalassaemia (four α-genes, n = 62), (ii) silent α-thalassaemia (three α-genes, n = 35) and (iii) homozygous α-thalassaemia (two α-genes, n = 12). Red blood cell (RBC) deformability measured in normoxia was not different between the three groups.
View Article and Find Full Text PDFArticle Synopsis
- - The study aimed to compare oxygen gradient ektacytometry parameters in sickle cell patients of different genotypes (SS, SC, S/β) and treatment methods (hydroxyurea vs. chronic red blood cell exchange).
- - Using a sample of 167 adults and children, the results showed that SC patients had better red blood cell (RBC) deformability and lower sickling susceptibility compared to untreated SS patients; also, SS patients under chronic exchange therapy exhibited improved parameters.
- - The findings indicate that the various genotypes and treatments influence RBC properties, with notable differences in stability during acute complications among SS patients.