Publications by authors named "K Kayano"
Article Synopsis
- * Researchers collected blood samples and analyzed the changes in granulocyte and monocyte subtypes before and after GMA using advanced mass cytometry techniques.
- * Findings indicate that specific activated neutrophil and monocyte subsets, which promote inflammation and T cell activation, are targeted by GMA, potentially explaining its therapeutic benefits in severe COVID-19 and similar inflammatory conditions.
Article Synopsis
- A new and efficient method to synthesize mugineic acids and 2'-hydroxynicotianamine was developed, using epoxide ring-opening reactions without the need for redox processes.
- Mugineic acid was produced in 6 steps from easily accessible materials, while the protected 2'-hydroxynicotianamine was made in 4 steps, with a dansyl group added for fluorescence detection.
- The final product, a dansyl-labeled nicotianamine iron complex, was successfully taken up by oocytes expressing specific transporters (ZmYS1 from maize and PAT1 from humans), demonstrating the effective transport of the synthesized probe.
Neutrophil phenotypes implicated in the pathophysiology of post-traumatic sepsis.
Front Med (Lausanne)
December 2022
Background: The disruption of immune homeostasis after trauma is a major cause of post-traumatic organ dysfunction and/or sepsis. Recently, a variety of neutrophil phenotypes with distinct functions have been identified and suggested as involved in various clinical conditions. The association between neutrophil phenotypes and post-traumatic immunodeficiency has also been reported, yet the specific neutrophil phenotypes and their functional significance in post-traumatic sepsis have not been fully clarified.
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- The study aimed to understand immune changes in critically ill COVID-19 patients during their recovery over a year.
- Researchers analyzed immune responses in patients at various recovery stages using advanced single-cell techniques, comparing their immune profiles with those of healthy individuals.
- Results showed increased levels of certain immune cells like T lymphocytes and natural killer cells in recovering patients, indicating a sustained immune response over the recovery period.
Background: Various animal models of sepsis have been developed to optimize sepsis treatment. However, therapeutic agents that were successful in animal models were rarely effective in human clinical trials. The cecal ligation and puncture (CLP) model is currently the gold standard for sepsis studies.
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