Application of silica monoliths for improved storage stability of metabolites in human plasma.

In metabolomic studies, sample collection and analysis are typically performed at separate locations, necessitating the transport and storage of samples. However, sample transport and storage conditions are often constrained by the available facilities. Specifically, metabolite levels in biological and food samples can fluctuate due to the activity of endogenous enzymes, depending on the transport and storage conditions.

Self-organized patterning of peristaltic waves by suppressive actions in a developing gut.

Gut peristalsis is a wave-like movement of a local contraction along the gut, and plays important roles in nutrient digestion and absorption. When peristaltic waves emerge in embryonic guts, randomly distributed origins of peristaltic waves (OPWs) become progressively confined to specific sites. We have investigated how this random-to-organized positioning is achieved using the caecum as a model in chicken embryos.

Human biodistribution and radiation dosimetry of two novel α-synuclein PET tracers, F-SPAL-T-06 and F-C05-05.

F-SPAL-T-06 and F-C05-05 are two novel positron emission tomography (PET) radioligands targeting α-synuclein fibrils. Our study aimed to evaluate the biodistribution, safety, and radiation dosimetry of each tracer in humans. Biodistribution and radiation dosimetry studies were carried out with two healthy volunteers for each tracer, F-SPAL-T-06 (one female and one male volunteer, both aged 63 years) and F-C05-05 (one female and one male volunteer, aged 63 and 73 years, respectively).

Effects of a Loosening Meditation Practice on Older Adults With Mild Cognitive Impairment: A Pilot Study.

Background Holistic medical practices, including meditation and mindfulness, are increasingly recognized for their benefits in mental health and stress reduction, with applications in clinical settings. However, their effects on older adults with mild cognitive impairment (MCI) remain underexplored. This study aimed to evaluate the impact of loosening meditation, a brief and accessible practice we developed, on this population.

Three-Dimensional In Vivo Kinematic Analysis of Kienböck Disease Treated with Arthroscopic Lunate Excision.

Purpose: Treatment options for advanced stage Kienböck disease primarily involve lunate excision, either in the context of proximal row carpectomy or in association with partial wrist fusion. This study aimed to investigate the in vivo three-dimensional carpal kinematics following arthroscopic lunate excision.

Methods: We analyzed carpal translation and rotation of the affected wrist in five patients who underwent arthroscopic lunate excision for stage IIIC Kienböck disease.