Publications by authors named "K Kaszala"
Background: The mechanisms underlying postoperative atrial fibrillation (POAF) remain unclear.
Objectives: The aim of this study was to test the hypothesis that targeted chemical ganglionated plexi (GP) modulation of all major left atrial-pulmonary vein GP using novel nanoformulated calcium chloride (nCaCl) can reverse postoperative neuroelectrical remodeling by suppressing vagosympathetic nerve activity and the localized inflammatory process, both critical substrates of POAF.
Methods: In a novel canine model of POAF with serial thoracopericardiotomies, sympathetic nerve activity (SNA), vagal nerve activity (VNA) and GP nerve activity (GPNA) were recorded; spontaneous and in vivo AF vulnerability were assessed; and atrial and circulating inflammatory markers and norepinephrine (NE) were measured to determine the neuroelectrical remodeling that promotes POAF and its subsequent modulation with nCaCl GP treatment (n = 6) vs saline sham controls (n = 6).
Article Synopsis
- - Transvenous leads are the standard method used for treating heart rhythm issues like bradyarrhythmia and tachyarrhythmia.
- - There are various risk factors for infections or complications related to cardiac devices, which involve both unchangeable patient characteristics and specific issues related to the device itself.
- - To improve safety during procedures and patient care, it’s crucial to focus on thorough patient screening, minimizing infection risks, selecting appropriate leads, and using proper implant techniques.
Article Synopsis
- Premature ventricular contractions (PVCs) are common in individuals with left ventricular (LV) systolic dysfunction, yet their prevalence in the general population is not well understood.
- A multicenter study evaluated the prevalence of frequent (PVCs >5%) and high burden (PVCs >10%) PVCs among patients monitored with ambulatory Holter monitors, analyzing demographics and left ventricle ejection fraction (LVEF).
- Results showed that PVCs >5% and >10% were present in 4% and 5% of participants, respectively, with higher prevalence in older males, while females had a lower occurrence of PVCs despite similar rates when LVEF <50%.
Background: The significance of autonomic dysfunction in premature ventricular contraction-induced cardiomyopathy (PVC-CM) remain unknown.
Objectives: Utilizing a novel "dual stressor" provocative challenge combining exercise with premature ventricular contraction (PVCs), the authors characterized the functional and molecular mechanisms of cardiac autonomic (cardiac autonomic nervous system) remodeling in a PVC-CM animal model.
Methods: In 15 canines (8 experimental, 7 sham), we implanted pacemakers and neurotelemetry devices and subjected animals to 12 weeks of bigeminal PVCs to induce PVC-CM.
Arrhythmias frequently accompany heart failure and left ventricular dysfunction. Tachycardias, atrial fibrillation, and premature ventricular contractions can induce a reversible form of dilated cardiomyopathy (CM) known as arrhythmia-induced CM (AiCM). The intriguing question is why certain individuals are more susceptible to AiCM, despite similar arrhythmia burdens.
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