Publications by authors named "K Karasova"
Article Synopsis
- The study aimed to investigate the relationship between two biomarkers, serum neurofilament heavy chain (sNfH) and chitinase 3-like 1 (sCHI3L1), and their impact on treatment response and disease activity in multiple sclerosis (MS).
- Conducted at the MS Centre in the Czech Republic, the research analyzed 459 samples from 57 MS patients over approximately 22 months.
- Results indicated that higher sNfH levels were linked to disease relapses and shorter treatment duration, while sCHI3L1 levels did not correlate with relapse, suggesting that sNfH may be a useful biomarker for monitoring MS treatment and disease progression.
Background: Serum neurofilaments (sNfs), especially the most investigated serum neurofilament light chain (sNfL), are promising biomarkers in multiple sclerosis (MS). However, their clinical utility is still limited, given the availability and costs of accessible analytical methods. The gold standard for the detection of sNfs is represented by the single molecule arrays (SIMOA).
View Article and Find Full Text PDFBackground: Intrathecal IgM synthesis has been identified as an adverse prognostic factor in patients with multiple sclerosis (MS); however, some studies have not confirmed this association. The objective of this study was to evaluate the clinical utility of intrathecal IgM synthesis for prediction of disease activity and disability in patients after the first demyelinating event of MS.
Methods: We conducted a single-centre prospective observational cohort study at the Department of Neurology, University Hospital Ostrava, Czech Republic.
The theory of Ayres Sensory Integration was formulated in the 1960s, and is also known as sensory integration (SI). It has been used in people with cerebral palsy (CP), though the research evidence for its effects in this population is contradictory and inconclusive. To fill in this knowledge gap, we conducted a scoping review of the body of literature on the topic, including any type of quantitative or qualitative research of SI in people with CP without any restrictions of age, language, geography, professionals involved, etc.
View Article and Find Full Text PDFObjective: To explore the characteristics and outcomes of vibroacoustic therapy (VAT) in adults experiencing pain. To give directions for future research and clinical applications of VAT in pain management for adults.
Design: Scoping review.