Publications by authors named "K Kandler"
Article Synopsis
- The Saharan Aerosol Longrange TRansport and Aerosol Cloud interaction Experiment (SALTRACE) conducted flight measurements to evaluate the structural properties of the Saharan air layer (SAL), focusing on its chemical, morphological, and optical characteristics during transport from Cape Verde and the Caribbean.* -
- The study found that SAL was predominantly dust (>90%) with minimal mixing (less than 1%) with other particles, and changes in the shape of the dust particles during transport were not statistically significant.* -
- A notable finding was a reduction in iron oxide content in transported SAL, which led to a decrease in dust light absorption, indicating the importance of including iron oxide size distribution in future aerosol research.*
Article Synopsis
- - In April 2023, tofersen, an antisense oligonucleotide, was FDA-approved for treating ALS after it significantly reduced levels of neurofilament light chain (NfL), a marker of neurodegeneration.
- - A follow-up study involving 24 ALS patients in Germany showed that while ALS functional scores declined, there was a notable reduction in both serum NfL and phosphorylated neurofilament heavy chain (pNfH) levels in the cerebrospinal fluid (CSF).
- - The therapy was considered safe, with no ongoing symptoms, despite some patients showing signs of immune response in the CSF, pointing to potential autoimmune reactions.
The medial nucleus of the trapezoid body (MNTB) in the auditory brainstem is the principal source of synaptic inhibition to several functionally distinct auditory nuclei. Prominent projections of individual MNTB neurons comprise the major binaural nuclei that are involved in the early processing stages of sound localization as well as the superior paraolivary nucleus (SPON), which contains monaural neurons that extract rapid changes in sound intensity to detect sound gaps and rhythmic oscillations that commonly occur in animal calls and human speech. While the processes that guide the development and refinement of MNTB axon collaterals to the binaural nuclei have become increasingly understood, little is known about the development of MNTB collaterals to the monaural SPON.
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- * Investigation into TDP-43 peptides as potential antigenic triggers for T-cell activation revealed weak responses in both ALS patients and healthy controls.
- * The findings imply that while there is a general increase in activated T cells in ALS, TDP-43 appears to function as a weak autoantigen, with no significant change in levels of auto-antibodies against it.
Article Synopsis
- ALS is a neurodegenerative disorder influenced by both genetic and epigenetic factors, leading to changes in how genes are expressed.
- Researchers identified an epigenetic signature related to ALS, called 'epiChromALS', by analyzing chromatin accessibility in blood cells of ALS patients, revealing connections to neuronal pathways.
- The study used advanced techniques to show that epigenetic changes in ALS can be observed not only in the brain but also in peripheral blood cells, indicating a potential link between these changes and the disease's progression.