Publications by authors named "K Kandiah"
Background: This study aimed to determine long-term outcomes of gastric endoscopic submucosal dissection (ESD) in Western settings based on the latest Japanese indication criteria, and to examine predictors of outcomes and complications.
Methods: Data were collected from consecutive patients undergoing gastric ESD at four participating centers from 2009 to 2021. Retrospective analysis using logistic regression and survival analysis was performed.
Article Synopsis
- The study emphasizes the need for individualized discussions between patients and their healthcare teams regarding management options for colitis-associated dysplasia to improve outcomes.
- A multidisciplinary group developed consensus statements through systematic reviews and expert recommendations, achieving high agreement on best practices.
- The final toolkit includes decision aids for both clinicians and patients to support shared decision-making about high cancer risk dysplasia management.
Article Synopsis
- Peroral endoscopic myotomy (POEM) is an effective, minimally invasive treatment for achalasia, yet it has high postoperative reflux rates, which can be addressed by using functional luminal imaging probes (FLIP) during the procedure.
- A study involving 142 patients across two UK medical centers showed that 90% had successful outcomes (Eckardt scores under 3) at 6 weeks post-surgery, with further improvements in symptom resolution rates in later cases.
- Shorter myotomies (less than 7 cm) demonstrated higher clinical success and lower proton-pump inhibitor usage, indicating tailoring myotomy length using FLIP data could enhance patient outcomes, though more research is necessary for refining optimal techniques.
Objective: Endoscopic resection (ER) often involves referral to tertiary centres with high volume practices. Lesions can be subject to prior manipulation and mischaracterisation of features required for accurate planning, leading to prolonged or cancelled procedures. As potential solutions, repeating diagnostic procedures is burdensome for services and patients, while even enriched written reports and still images provide insufficient information to plan ER.
View Article and Find Full Text PDFBackground: Single-agent methotrexate (MTX) is commonly used as first-line treatment for low-risk gestational trophoblastic neoplasia (LR-GTN), although no international consensus exists on the optimal treatment regimen to maximise complete hCG response (CR) and minimise relapse rates. Current regimens differ in the route of administration, dose scheduling, and use of flat-dose, body surface area (BSA)- or weight-based dosing. In the UK a methotrexate-folinic acid (MTX-FA) 8-day 50 mg intramuscular flat-dose regimen is used, with 15 mg oral folinic acid rescue.
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