A gain-of-function mutation in zinc cluster transcription factor Rob1 drives Candida albicans adaptive growth in the cystic fibrosis lung environment.

Candida albicans chronically colonizes the respiratory tract of patients with Cystic Fibrosis (CF). It competes with CF-associated pathogens (e.g.

and evaluation of antifungal combinations against azole-resistant isolates.

Azole resistance in (Af) has become a widespread threat and a major concern for optimal management of patients with invasive aspergillosis (IA). Combination of echinocandins with azoles is an attractive alternative option for the treatment of IA due to azole-resistant Af strains. The aim of this study was to evaluate the and combination of caspofungin (CAS) with either voriconazole (VRZ) or posaconazole (PSZ).

Aspergillus flavus genetic structure at a turkey farm.

Background: The ubiquitous environmental fungus Aspergillus flavus is also a life-threatening avian pathogen.

Objectives: This study aimed to assess the genetic diversity and population structure of A. flavus isolated from turkey lung biopsy or environmental samples collected in a poultry farm.

In Vivo Efficacy of Voriconazole in a Model of Invasive Infection Due to Azole-Susceptible or Resistant Isolates.

is an environmental filamentous fungus responsible for life-threatening infections in humans and animals. Azoles are the first-line treatment for aspergillosis, but in recent years, the emergence of azole resistance in has changed treatment recommendations. The objective of this study was to evaluate the efficacy of voriconazole (VRZ) in a model of invasive infection due to azole-susceptible or azole-resistant isolates.

Case Report: Allergic Bronchopulmonary Aspergillosis Revealing Asthma.

Allergic bronchopulmonary aspergillosis (ABPA) is an immunological pulmonary disorder caused by hypersensitivity to which colonizes the airways of patients with asthma and cystic fibrosis. Its diagnosis could be difficult in some cases due to atypical presentations especially when there is no medical history of asthma. Treatment of ABPA is frequently associated to side effects but cumulated drug toxicity due to different molecules is rarely reported.