Publications by authors named "K Kaji"
Imeglimin promotes glucose-stimulated insulin secretion in the pancreas in a glucose-dependent manner and inhibits gluconeogenesis in the liver. Meanwhile, imeglimin can improve mitochondrial function in hepatocytes. We used a nondiabetic metabolic dysfunction-associated steatohepatitis (MASH) model to examine the effects of imeglimin on MASH independent of its glucose-lowering action.
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- * In rats fed a special high-fat diet, cabozantinib treatment significantly decreased liver inflammation and fibrosis but did not change fat accumulation in liver cells, indicating its targeted impact on fibrosis rather than overall liver health.
- * The study found that cabozantinib reduced certain harmful liver cell activations and inflammatory responses without hindering liver cell regeneration, suggesting its potential for aiding liver health in cancer treatment.
Background: It is difficult to evaluate adequate dose of heparin for cardiopulmonary bypass (CPB) by activated clotting time (ACT) in a patient receiving both heparin and dabigatran because dabigatran can also prolong ACT. We evaluated the effect of dabigatran by thromboelastography (TEG) to determine adequate heparin dose for CPB.
Case Presentation: An 81-year-old woman receiving both heparin and dabigatran was scheduled for an emergency surgical repair of iatrogenic atrial septal perforation.
Article Synopsis
- Alcohol-associated liver disease (ALD) leads to significant liver damage and currently lacks effective treatments; this study investigates the potential of elafibranor (EFN), a dual PPARα and PPARδ agonist, as a therapeutic option.
- Using a mouse model, the researchers induced ALD and evaluated the effects of EFN on liver fibrosis and gut health by administering EFN and conducting various molecular analyses.
- Results showed that EFN treatment significantly reduced liver damage and fibrosis, improved lipid metabolism, and strengthened the intestinal barrier, suggesting its potential as a treatment for ALD.