Flagellin-Fused Protein Targeting M2e and HA2 Induces Innate and T-Cell Responses in Mice of Different Genetic Lines.

Efficient control of influenza A infection can potentially be achieved through the development of broad-spectrum vaccines. Recombinant proteins incorporating conserved influenza A virus peptides are one of the platforms for the development of cross-protective influenza vaccines. We constructed a recombinant protein Flg-HA2-2-4M2ehs, in which the extracellular domain of the M2 protein (M2e) and the sequence (aa76-130) of the second subunit of HA (HA2) were used as target antigens.

[The initial period of functioning of the Medical Faculty of the Imperial University of the Saint Vladimir and teaching of medical police].

The article considers the circumstances of the beginning of teaching medical police at St.Vladimir Imperial University in Kiev that was investigated for the first time. It was established that the medical police were taught as one of academic disciplines at the Department of State Medicine Studies.

The Potential of Influenza HA-Specific Immunity in Mitigating Lethality of Postinfluenza Pneumococcal Infections.

Influenza virus infections pre-dispose an individual to secondary pneumococcal infections, which represent a serious public health concern. Matching influenza vaccination was demonstrated helpful in preventing postinfluenza bacterial infections and associated illnesses in humans. Yet, the impact of influenza hemagglutinin (HA)-specific immunity alone in this dual-infection scenario remains elusive.

[I. A. Petrovsky and Implementation of Qualitative Approach into Clinical Medicine].

The article covers the life and the work of Ivan A. Petrovsky, doctor of medicine. His contribution into propaganda in the Russian Empire of the idea of French physician Pierre-Charles-Alexandre Louis (1787-1872) concerning necessity of applying the statistical method in the clinical medicine.

[F. G. Yanovsky, the Classic of National Medicine].

In Russia, the elite of therapy took shape in the first decades of XX century. Feofil Gavrilovich Yanovsky, professor of the St. Vladimir Kiev University was one of elite leaders.