Publications by authors named "K K Timilsina Bhandari"
The Sustainable Development Goals (SDGs) emphasize the importance of food safety, prolonged shelf life, and reduced food waste, all of which rely on effective food preservation methods. Bacteriocins, natural antimicrobial substances produced by lactic acid bacteria (LAB), have potential applications in food preservation. This review highlights the role of LAB-derived bacteriocins in preserving food.
View Article and Find Full Text PDFGlobally, rice bacterial blight disease causes significant yield losses. Metabolomics is a vital tool for understanding this disease by analyzing metabolite levels and pathways involved in resistance and susceptibility. It enables the development of disease-resistant rice varieties and sustainable disease management strategies.
View Article and Find Full Text PDFHemorrhagic pleural effusion as the sole manifestation of pancreatitis is exceedingly rare and often presents diagnostic challenges due to its misleading symptoms. We report the case of an adult male with a large left-sided black pleural effusion secondary to chronic necrotizing pancreatitis. The patient presented with progressive shortness of breath and cough, with a history of alcohol use and a previous diagnosis of acute severe pancreatitis.
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- Small extracellular vesicles (sEVs) in pancreatic ductal adenocarcinoma (PDAC) carry specific miRNAs that influence cancer progression, but the reasons for their selective enrichment are not fully understood.
- The study focuses on Serine/Arginine-rich splicing factor 1 (SRSF1), an onco-protein overexpressed in PDAC, and how modifications like phosphorylation and arginine methylation affect sEV miRNA levels.
- Treatment with arginine methyltransferase inhibitors increased levels of the specific miRNA miR-1246 in PDAC cells, suggesting that arginine methylation reduces SRSF1's ability to bind this miRNA and enrich it in sEVs,
Introduction And Importance: Although pulmonary artery involvement is well recognized, the incidence of interstitial lung disease (ILD) with Takayasu arteritis is very rare. The pathophysiology of ILD in Takayasu is still incompletely understood, in contrast to several studies establishing the relationship between ANCA-associated vasculitis and ILD. The management of this patient involved a multidisciplinary approach with long-term follow-up.
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