Lipopolysaccharide differentially alters systemic and brain glucocorticoid levels in neonatal and adult mice.

Glucocorticoids (GCs) are secreted by the adrenal glands and increase in response to stressors (e.g., infection).

Early-life gut inflammation drives sex-dependent shifts in the microbiome-endocrine-brain axis.

Despite recent advances in understanding the connection between the gut microbiota and the adult brain, significant knowledge gaps remain regarding how gut inflammation affects brain development. We hypothesized that gut inflammation during early life would negatively affect neurodevelopment by disrupting microbiota communication to the brain. We therefore developed a novel pediatric chemical model of inflammatory bowel disease (IBD), an incurable condition affecting millions of people worldwide.

Design of Silica-Cobalt Composite Microporous Structures with Dispersed Carbon Particles for Highly Permselective Gas Separation Membranes.

Metal-doped silica membranes, fabricated via the sol-gel technique using metal nitrates, hold promise for high-temperature separation processes, such as H separation in steam reforming reactions. However, controlling the status of the doped metal is challenging and often leads to defect formation owing to the aggregation of metal oxides. In this study, we designed a uniform carbon-Co-SiO ceramic membrane using a one-pot sol-gel method with copolymerization, employing tetraethoxysilane and cobalt acetylacetone(III) (Co-(acac)) as precursors.

Co-presence of PtNi nanowires and ionic liquid in carbon mesopores enhances electrocatalytic oxygen reduction activity.

The electrocatalytic activity of PtNi nanowires is enhanced by the co-presence of ionic liquid in carbon mesopores. Three-dimensional transmission electron microscopy tomography and surface-enhanced infrared absorption spectroscopy confirm the co-presence of PtNi nanowires and ionic liquid inside carbon mesopores even under electrochemical conditions.