Reactive oxygen species control protein degradation at the mitochondrial import gate.

While reactive oxygen species (ROS) have long been known to drive aging and neurodegeneration, their persistent depletion below basal levels also disrupts organismal function. Cells counteract loss of basal ROS via the reductive stress response, but the identity and biochemical activity of ROS sensed by this pathway remain unknown. Here, we show that the central enzyme of the reductive stress response, the E3 ligase Cullin 2-FEM1 homolog B (CUL2), specifically acts at mitochondrial TOM complexes, where it senses ROS produced by complex III of the electron transport chain (ETC).

Suppression of colorectal cancer growth: Interplay between curcumin and metformin through DMT1 downregulation and ROS-mediated pathways.

The rising incidence of colorectal cancer (CRC) poses significant healthcare challenges. This study explored the therapeutic potential of combined curcumin (CUR) and metformin (MET) treatment in CRC models. Our findings indicate that the combination treatment (COMB) effectively downregulates the expression of divalent metal transporter-1 (DMT-1), leading to a reduction in cell proliferation aligned with suppression of the pAKT/mTOR/Cyclin D1 signaling pathway.

Synergetic pyrolysis of lithium-ion battery cathodes with polyethylene terephthalate for efficient metal recovery and battery regeneration.

Spent LiNiCoMnO (x + y + z = 1) and polyethylene terephthalate are major solid wastes due to the growing Li-ion battery market and widespread plastic usage. Here we propose a synergistic pyrolysis strategy to recover valuable metals by thermally treating LiNiCoMnO and polyethylene terephthalate. With polyethylene terephthalate assistance, LiNiCoMnO decomposes at 400 °C, and fully converts to LiCO, MnO, and Ni-Co alloy at 550 °C within 30 min, using a 1.

The Effect of Music Distraction on Dental Anxiety During Invasive Dental Procedures in Children and Adults: A Meta-Analysis.

Dental anxiety and odontophobia are common issues, leading to challenges with oral hygiene and dental health. Music distraction offers an effective and side effect-free solution to alleviate pain and increase the acceptability of dental treatments. Our meta-analysis aimed to assess the efficacy of music distraction in reducing patient anxiety during invasive dental procedures in children and adults.

Energy Consumption Minimization with SNR Constraint for Wireless Powered Communication Networks.

The article addresses the energy consumption minimization problem in wireless powered communication networks (WPCNs) and proposes a time allocation scheme, named DaTA, which is based on the Different Target Simultaneous Wireless Information and Power Transfer (DT-SWIPT) scheme such that the wireless station can share the remaining energy after transmission to the Hybrid Access Point (HAP) to those who have not transmitted to the HAP to minimize the energy consumption of the WPCN. In addition to proposing a new frame structure, the article also considers the Signal-to-Noise (SNR) constraint to guarantee that the HAP can successfully receive data from wireless stations. In the article, the problem of minimization of energy consumption is formulated as a nonlinear programming model.