Publications by authors named "K K Saran"
Controlling Glycemic Variability in Non-diabetic Sepsis Patients: A Step toward Precision in Critical Care.
Indian J Crit Care Med
January 2025
Prakash J, Vaibhaw V, Saran K. Controlling Glycemic Variability in Non-diabetic Sepsis Patients: A Step toward Precision in Critical Care. Indian J Crit Care Med 2025;29(1):6-7.
View Article and Find Full Text PDFHuman breath gas analysis is a noninvasive disease diagnostic approach used to identify different pathological conditions in the human body. Monitoring breath acetone (CHO) and ammonia (NH) as biomarkers is vital in diagnosing diabetes mellitus and liver disorders, respectively. In this article, the quartz-enhanced photoacoustic spectroscopy (QEPAS) technique is proposed and demonstrated for measuring CHO and NH in human exhaled breath samples.
View Article and Find Full Text PDFClinical pathway development to standardize pharmacological medication management of agitation in pediatric inpatient settings.
J Can Acad Child Adolesc Psychiatry
July 2024
Objective: Acute agitation in pediatrics is commonly encountered in hospital settings, can contribute to significant physical and psychological distress, and management is highly varied in practice. As such, the development of a standardized pharmacologic guideline is paramount. We aimed to develop a novel clinical pathway (CP) for management of acute agitation for all hospitalized pediatric patients in Canada.
View Article and Find Full Text PDFArticle Synopsis
- The meta-analysis aimed to assess how the modified NUTRIC (mNUTRIC) score affects mortality rates in critically ill patients.
- A total of 31 studies involving over 13,000 patients were reviewed, showing the mNUTRIC score has strong discrimination ability for predicting mortality (sAUC of 0.80).
- The findings suggest that the mNUTRIC score effectively differentiates between critically ill patients and can help predict their risk of dying, regardless of the specific cut-off values used.
Article Synopsis
- Sepsis-induced immunosuppression may be treatable with immunomodulatory drugs like MIP, which promotes a Th1 immune response.
- A systematic review and meta-analysis was conducted using multiple databases to evaluate the effectiveness of MIP on clinical outcomes in sepsis patients.
- Although the study found a 43% reduction in mortality for MIP patients compared to controls, this wasn't statistically significant, yet there were positive trends suggesting MIP could improve outcomes like reduced secondary infections and a shorter ICU stay.