Publications by authors named "K K Rump"
Article Synopsis
- * A study of 363 sepsis patients in Germany analyzed plasma samples on days 1 and 4, identifying 87 and 95 significantly different proteins related to survival outcomes, using statistical methods and machine learning for analysis.
- * The research highlighted shifts in protein networks linked to blood coagulation and immune responses over time, suggesting potential new therapeutic targets and a focus on the innate immune system in treating sepsis.
Introduction: In sepsis treatment, achieving and maintaining effective antibiotic therapy is crucial. However, optimal antibiotic dosing faces challenges due to significant variability among patients with sepsis. Therapeutic drug monitoring (TDM), the current gold standard, lacks initial dosage adjustments and global availability.
View Article and Find Full Text PDFAquaporins (AQPs), a family of membrane proteins that facilitate the transport of water and small solutes, have garnered increasing attention for their role in sepsis, not only in fluid balance but also in immune modulation and metabolic regulation. Sepsis, characterized by an excessive and dysregulated immune response to infection, leads to widespread organ dysfunction and significant mortality. This review focuses on the emerging roles of aquaporins in immune metabolism and their potential as therapeutic targets in sepsis, with particular attention to the modulation of inflammatory responses and organ protection.
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- Sepsis involves intricate immune responses, and the protein GILZ is crucial in balancing inflammation and anti-inflammation; this study looks at how different forms of GILZ transcripts can be used to categorize patients and improve treatment effectiveness with glucocorticoids.
- The research involved analyzing RNA from blood samples of 121 sepsis patients to measure GILZ transcript variants and to see their relation to mortality rates and glucocorticoid responses.
- Findings indicate that high levels of GILZ transcript variant 1 (GILZ TV 1) significantly correlate with increased 30-day mortality in sepsis patients, especially the first eight days after onset, suggesting it can help identify patients who may not
Background: Sepsis, a life-threatening condition caused by the dysregulated host response to infection, is a major global health concern. Understanding the impact of viral or bacterial pathogens in sepsis is crucial for improving patient outcomes. This study aimed to investigate the human cytomegalovirus (HCMV) seropositivity as a risk factor for development of sepsis in patients with COVID-19.
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