Topiramate Is Safe for Refractory Neonatal Seizures: A Multicenter Retrospective Cohort Study of Necrotizing Enterocolitis Risk.

Background: A previously published, single-institution, case series suggested an association between topiramate administration in neonates and subsequent development of necrotizing enterocolitis (NEC). This contradicted our more extensive experiences using topiramate in this population. We therefore studied safety and tolerability of topiramate for treating refractory neonatal seizures, hypothesizing that the risk of developing NEC following topiramate exposure was low and that most infants tolerate topiramate.

[Determination of the risk factors, their characteristics and the nature of the reporting in the primary and secondary prevention of rheumatism].

Basing on the results of a long-term prospective study (1960-1984) of 1310 patients with rheumatic fever and previous investigations the authors have singled out syndromes and complexes of risk factors of primary morbidity, recurrence and different outcomes of rheumatic fever. The main syndromes of risk factors of primary morbidity of rheumatic fever are chronic focal infection, everyday, age-sex and genetic factors, those of recurrences, the above factors and insufficient secondary prevention.