Morphology controlled CuBiS nanostructures: superior electrocatalytic sensing of organic nitro compounds.

Addressing the pressing need to develop affordable and efficient catalysts is essential. In this study, we successfully synthesized CuBiS nanostructures with a modified morphology using three different nitrogen bases: DBN, DBU, and DABCO a hydrothermal technique. These nanostructures were used for the electrochemical detection of organic nitro groups, a previously unexplored application for this material.

RhoA Allosterically Activates Phospholipase Cε via its EF Hands.

Phospholipase Cε (PLCε) cleaves phosphatidylinositol lipids to increase intracellular Ca and activate protein kinase C (PKC) in response to stimulation of cell surface receptors. PLCε is activated via direct binding of small GTPases at the cytoplasmic leaflets of cellular membranes. In the cardiovascular system, the RhoA GTPase regulates PLCε to initiate a cardioprotective pathway, but the underlying molecular mechanism is not known.

Effective communication by health care workers to promote HPV vaccination: Lessons learned from Kenya, India, and Nigeria.

Health care workers play an essential role in maintaining the public trust in vaccination programmes globally, and more specifically, in low- and middle-income countries. This role is particularly important in building trust in the human papillomavirus (HPV) vaccine. While there are many factors that affect HPV vaccine acceptance, health care workers are one of the most critical influences in the decision-making process among parents as well as adolescent girls.

Evidence for an HPV one-dose schedule.

The World Health Organization has recently updated their dosing schedule recommendations for the human papillomavirus (HPV) vaccine to include a single-dose schedule. We review the biologic plausibility of a single dose, the evidence from clinical trials, post-licensure observational studies, and mathematical modeling for a single-dose schedule. We also discuss the implications of countries switching to a single-dose program from a two or three-dose schedule.

Status of HPV disease and vaccination programmes in LMICs: Introduction to special issue.

Sexually transmitted human papillomavirus (HPV) infections are extremely common in both men and women and while most will clear naturally, some may progress to cervical cancer and other cancers. Despite the availability of prophylactic vaccines and well-established screening and treatment practices, the global burden of HPV-related disease remains high, particularly in low-and-middle-income countries (LMICs). We outline the current global epidemiology of cervical cancer disease incidence and mortality, with the highest burden in Africa and Asia.