[Preclinical pharmacokinetics of pefloxacin].

The substance and tablets of pefloxacin mesilate manufactured by the Urals Polytechnical University and the National Research Centre of Antibiotics were studied on rats and dogs with the drug oral administration in single and multiple doses equivalent to the human ones. The bioavailability of the drug was good and its blood levels were efficient for a prolonged period (at least 24 hours) after a single oral administration. No cumulation of the antibiotic after its repeated use was observed.

[Sulacillin in the treatment of bronchopulmonary diseases].

Antibiotic susceptibility of 279 strains of gram-positive and gram-negative isolates from patients with bronchopulmonary infections was tested. It was shown that the frequency of resistance to ampicillin and sulacillin amounted to 36.5 and 28.

[Analysis of ceftazidime and ampicillin tissue distribution using physiologic models of pharmacokinetics].

Physiological models of ceftazidime and ampicillin pharmacokinetics were used to study accumulation of the antibiotics in the tissue interstitial space and to analyze the influence of the regional blood flow rate on the accumulation. For the control of the model adequacy, the published pharmacokinetic data on the distribution of ceftazidime and ampicillin in serum and "skin blister" fluid were used. The pharmacokinetic profiles calculated from the equations of the physiological models including Kp corresponded to the kinetics of the changes in the content of the cephalosporins and penicillins in the tissue homogenates.

Use of gentamicin physiologically-based model for individual dosing.

A new approach to fixing initial doses of gentamicin (GM) for i.m. administration (that is most commonly used anyway) is discussed.

[An animal experiment on transplacental transport of ceftazidime at various terms of pregnancy].

The experiments on rats revealed good transplacental transfer of ceftazidime to the fetus. The level of the transfer increased with increasing of the pregnancy term. The antibiotic concentration in the fetal tissues exceeded the MIC for opportunistic organisms.