Publications by authors named "K K Lemberg"
Article Synopsis
- The study reviewed six pediatric osteosarcoma patients with brain metastases at Johns Hopkins Hospital, revealing a grim median survival of just 2.5 months post-diagnosis.
- Despite various treatments like chemotherapy, surgery, and radiation, most outcomes were fatal, although one patient showed a remarkable 13-month survival with a combination treatment, suggesting the potential of multimodal therapies.
- The findings stress the importance of careful monitoring for neurological symptoms and highlight the need for further research into new treatment strategies and the biology of metastasis to improve patient outcomes.
Background: In children and adolescents/young adults (CAYA) with neurofibromatosis type I (NF1), associations between anthropometric measurements, plexiform neurofibroma (pNF) tumor volume (TV), and treatment history are unknown.
Methods: We retrospectively investigated anthropometrics in CAYA on the National Cancer Institute (NCI) NF1 Natural History Study who had pNF TV assessed by imaging (n = 106). We determined CDC height/weight percentiles and estimated Preece-Baines (PB) height growth curve parameters.
Bardet-Biedl Syndrome (BBS) is an autosomal recessive non-motile ciliopathy, caused by mutations in more than twenty genes. Their expression leads to the production of BBSome-building proteins or chaperon-like proteins supporting its structure. The prevalence of the disease is estimated at 1: 140,000 - 160,000 of life births.
View Article and Find Full Text PDF