A mining code for regulating lunar water ice mining activities.

Despite the increasing number of space launches, growth of the commercial space sector, signing of the Artemis Accords, maturation of space mining technologies, the emergence of a regulatory environment through domestic legislation, and a comprehensive body of international law, an intergovernmental governing authority has yet to be established to manage mining activities on the Moon. We developed a Lunar Mining Code and mapping tool to regulate and manage prospecting and exploration activities for water ice at the Moon's poles. The Lunar Mining Code is composed of a notification system to manage prospecting, a contract system for issuing exploration licenses to allotted areas on the Moon, and best mining practices and principles to promote equal access and safeguard the lunar environment.

Predictive Factors of State Licensure Board Disciplinary Actions in Occupational Therapy.

Importance: One primary function of occupational therapy state licensure boards (SLBs) is the discipline of ethical misconduct by licensed occupational therapy practitioners. However, SLB sanctioning is poorly understood by practitioners, regulators, and the public.

Objective: To identify predictors of occupational therapy practitioner sanctioning outcomes in the United States.

A blended genome and exome sequencing method captures genetic variation in an unbiased, high-quality, and cost-effective manner.

We deployed the Blended Genome Exome (BGE), a DNA library blending approach that generates low pass whole genome (1-4× mean depth) and deep whole exome (30-40× mean depth) data in a single sequencing run. This technology is cost-effective, empowers most genomic discoveries possible with deep whole genome sequencing, and provides an unbiased method to capture the diversity of common SNP variation across the globe. To evaluate this new technology at scale, we applied BGE to sequence >53,000 samples from the Populations Underrepresented in Mental Illness Associations Studies (PUMAS) Project, which included participants across African, African American, and Latin American populations.

A Closer Look into White Adipose Tissue Biology and the Molecular Regulation of Stem Cell Commitment and Differentiation.

White adipose tissue (WAT) makes up about 20-25% of total body mass in healthy individuals and is crucial for regulating various metabolic processes, including energy metabolism, endocrine function, immunity, and reproduction. In adipose tissue research, "adipogenesis" is commonly used to refer to the process of adipocyte formation, spanning from stem cell commitment to the development of mature, functional adipocytes. Although, this term should encompass a wide range of processes beyond commitment and differentiation, to also include other stages of adipose tissue development such as hypertrophy, hyperplasia, angiogenesis, macrophage infiltration, polarization, etc.