Publications by authors named "K K Holst"
To evaluate the reproductive experiences of physicians across gender and specialty. Between November and December 2021, we surveyed nontrainee physicians of all genders at a single quaternary institution using a modified version of an existing survey instrument. Experiences with family planning, fertility, pregnancy, and parental leave were assessed.
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- Patients with congenital heart disease often require reoperative surgeries, especially for valve issues, and a study tracked 1960 adult patients undergoing repeat surgeries from 1993 to 2022 to analyze outcomes.* -
- Among the 502 patients studied, most underwent surgeries involving multiple valves, with low early mortality rates of 4.2%, particularly for elective operations.* -
- Key factors influencing mortality included patient age, heart function, and the urgency of the surgery, indicating that timely referrals can improve surgical outcomes.*
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- Coronary artery occlusion (CO) is a serious complication during transcatheter aortic valve replacement (TAVR) and this study aimed to evaluate a predictive modeling algorithm to improve risk assessment during the planning phase.
- During the study period, 116 patients identified as at higher risk for CO were analyzed using computational modeling to guide procedural adjustments, leading to various modifications like intentional laceration and the use of chimney stents.
- Ultimately, no instances of coronary artery compromise occurred in either the high-risk patients with modifications or the low-risk group, indicating that predictive modeling significantly enhances TAVR planning effectiveness.
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- Patients with bicuspid aortic valve (BAV) often experience aortic stenosis and aortopathy, but their aortic arch geometry has been poorly quantified, leading to subjective clinical classifications.
- This study analyzed 3D aortic arch and BAV geometry using pre-TAVR computed tomography in 59 patients, focusing on various morphological features of the valve and the aortic structure.
- Results showed a bimodal distribution of valve shapes, complex 3D variations in aortic arch geometry, and established quantitative subgroups based on curvature and area changes, enhancing understanding of aortic geometry in BAV and aortic stenosis.
Aortic stenosis (AS) contributes to significant cardiovascular morbidity and mortality worldwide, and the natural history from symptoms to ventricular decompensation, heart failure, and death has been well documented. For more than 2 decades, technologies including imaging and biomarkers have shown a promising ability to detect myocardial damage associated with AS before symptoms arise. Current treatment guidelines rely heavily on symptoms or ventricular decompensation as triggers for aortic valve intervention.
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