[Antiradiation effects of lactoferrin].

The propose of these examination was studied antiradiation effect of lactoferrin (LF). It was determined, that subcutaneous injection LF (65 or 300 mkg/kg) guinea-pigs irradiated after 1-14 days after of total gamma-irradiation (2.5 Gr) had therapeutically effect attached to the bone marrow form of acute radiation disease (ARD).

[Infection syndrome in acute radiation sickness patients subjected to Chernobyl accident].

In spite of intensive antimicrobial prophylaxis and therapy, most patients with acute radiation sickness I-IV severity grade (dose of 0.1-13.7 Gy) developed infections caused by bacteria, fungi and viruses.

[Antiradiation effects of leucynferon on dogs and guinea pigs].

In experiments with two species of animals (dogs, guinea pigs) irradiated with sublethal and lethal doses of gamma-rays, it was observed, that leucynferon had antiradiation effect. Course of injections: dogs--8 injections subcutaneus: 2.0 ml (1, 3, 5, 8, 12, 14, 21, 34 days after irradiation); guinea pigs--14 injections subcutaneus, 0.

[Radiation damage to the hemopoietic system of mice, carriers of the leukemia virus].

The experiments with AKR mice, that are carriers of the T-cell leukemia virus showed their higher radiosensitivity as compared to (CBA x C57Bl)F1 mice in respect of survival and hemopoietic status. The regular patterns observed are presumed to result from lower ability of AKR mice to repair radiation damage and provide resistance to infections.

[Therapeutic antiradiation properties of leukinferon].

In experiments with three species of animals (mice, rabbits, monkeys) irradiated with sublethal and lethal doses of gamma-irradiation, it was observed, that leukinferon used in 4 hours or 10 days after provided antiradiation therapeutical effect. When lethal dose was used (mice) the survival of animals was significantly increased. The preparation decreased depression of the functional activity of leukocytes as it was observed with IFH-alpha and gamma-production.