[The cellular mechanisms of antianthrax immunity].

The influence of the vaccination of mice and volunteers on the activity of natural killer cells (NKC) and K cells, the effectors of natural and antibody-dependent cytotoxicity of cells, was studied. Both types of killer cells were found to take an active part in the vaccinal process during the whole term of observation. The changes revealed in this study were characterized by two phases.

[The characteristics of the antibody response of animals immunized with components of the surface structures of Francisella tularensis].

Antibody formation in animals immunized with one of the components of F. tularensis surface structures was studied. The time course of antibody formation in 20 hamadryas baboons was studied in the passive hemagglutination (PHA) test, microagglutination (MA) test, and indirect enzyme immunoassay, used for the determination of IgG, IgA and IgM antibodies.

[The use of microdot immunoenzyme analysis with visual detection for the determination of tularemia antibodies].

The possibility of using the micropoint enzyme immunoassay (EIA) on a nitrocellulose membrane with the visual evaluation of results for the detection of tularemia IgG antibodies in hamadryas baboons at the postvaccinal period has been studied. The sensitivity of this assay has been compared with that of the passive hemagglutination (PHA) test, the microagglutination (MA) test and EIA with the spectrophotometric evaluation of results in plates. As shown in this study, EIA in the above-mentioned modification can be successfully used for the detection of tularemia antibodies in the blood serum.