Publications by authors named "K K Eaton"
Purpose: Patients with KRAS mutant non-small cell lung cancer (NSCLC) have limited therapeutic options. Based on activity of nuclear export inhibition in preclinical models, we evaluated this strategy in previously treated advanced KRAS mutant NSCLC.
Patients And Methods: The primary outcome of this multi-center phase 1/2 dose escalation trial of selinexor plus docetaxel was safety and tolerability.
Article Synopsis
- Pinfish are abundant in the Gulf of Mexico and western Atlantic Ocean, playing a vital role in marine food webs, but their response to climate change is not well understood.
- Genetic analysis showed high connectivity among pinfish populations across different temperatures, indicating low potential for local adaptation.
- Thermal tolerance tests revealed similar upper temperature limits across various locations, suggesting southern populations may be more vulnerable to ocean warming.