From Crisis to Clarity: Retropupillary Iris-Claw Lens and Iris Cerclage Techniques for Post-traumatic Cataract Rehabilitation.

This study details two cases of traumatic cataracts with a history of blunt trauma. Both presented with progressive vision loss, mydriasis, and zonular dialysis. The surgical intervention involved complete cataractous lens removal, anterior vitrectomy, iris cerclage with 10-0 prolene sutures, and retropupillary iris-claw lens fixation.

Structure and dynamics of piperidinium based amino acid ionic liquids: a computational investigation.

Context: There has been growing interest in amino acid ionic liquids because of their low-cost synthesis and superior biodegradability and biocompatibility compared to traditional ionic liquids. In this study, we have investigated the structure and dynamics of three ionic liquids consisting of N-butyl N-methyl piperidinium [Pip] cation with amino acid (lysine [Lys], histidine [His], and arginine [Arg]) anions. The radial distribution functions, the spatial distribution functions, and the coordination numbers have been used to analyze the structure in the bulk phase.

Solid dispersion of alectinib HCl: preclinical evaluation for improving bioavailability and establishing an IVIVC model.

Objective: Alectinib HCl (ALB-HCl) is a BCS class IV molecule with low solubility and low oral bioavailability. Owing to its low bioavailability, a high dose of ALB-HCl is recommended with food to meet clinical efficacy. Thus, there is a need for a delivery system to overcome the bioavailability concerns.

Capacity building in obstetric ultrasound: Impact of simulation based clinical teaching on resident training at a health facility in India.

Objective: Current postgraduate curriculum in India lacks practical training in ultrasound for residents in obstetrics and gynecology. The objective of this study was to develop and assess impact of a capacity building program utilizing clinical teaching and simulation to enhance knowledge and skills of residents at a healthcare facility in India.

Methods: A training program comprising of 14 modules on basic obstetric ultrasounds was created over 3 months.

Structural and mechanistic insights into oxidative biaryl coupling to form the arylomycin core by an engineered CYP450.

Arylomycin, a potent antibiotic targeting bacterial signal peptidase, is difficult to synthesize experimentally due to its poor to moderate yields and the formation of a mixture of compounds. A recent experimental bioengineering work shows that the core of arylomycin can be efficiently synthesized by engineering the cytochrome P450 enzyme from sp.; however, the mechanism of the same was not elucidated.