Publications by authors named "K K Chandrababu"
Parkinson's Disease (PD) is a neurodegenerative disorder marked by the depletion of dopaminergic neurons. Recent studies highlight the gut-liver-brain (GLB) axis and its role in PD pathogenesis. The GLB axis forms a dynamic network facilitating bidirectional communication between the gastrointestinal tract, liver, and central nervous system.
View Article and Find Full Text PDFTherapeutic application of bacterial cellulose, a polymer produced by fermentative growth of bacteria, is often challenged by low yields and absence of high yielding strains. The current study reports the synthesis and characterization of bacterial cellulose from a novel microbial consortium of Weissela confusa, Neobacillus drentensis, and Bacillus sp. isolated from mother of vinegar and identified by 16S rDNA typing.
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- SARS-CoV-2 has caused significant negative effects on global health and economies, leading many individuals to experience long-term symptoms known as 'long-COVID'.
- Long-COVID is characterized by lasting symptoms lasting over 12 weeks post-infection, which can involve neurological and mental health challenges.
- The review highlights the importance of understanding the neurological basis of these symptoms, discusses management strategies for patients, and emphasizes the need for further research on long-COVID's impacts and treatment.
Article Synopsis
- - The study focuses on the fibrillation of therapeutic peptides, specifically a 29-residue peptide called PepA and its modified versions, PepB and PepC, to understand how structural changes can influence fibrillation and improve drug development.
- - Different modifications, such as amidation of PepA's C-terminus and the substitution of Ser16 in PepC, were analyzed through various techniques, revealing that PepA and PepB formed fibrils while PepC did not and remained structurally stable.
- - Real-time stability analyses indicated that differences in peptide charge and formulation pH affected fibrillation rates, with stress tests revealing the presence of previously undetectable oligomers, suggesting that formulation stability is crucial for preventing fibrillation during storage
Parkinson's disease (PD) is a neurodegenerative disorder, prevalent in the elderly population. Neuropathological hallmarks of PD include loss of dopaminergic cells in the nigro-striatal pathway and deposition of alpha-synuclein protein in the neurons and synaptic terminals, which lead to a complex presentation of motor and non-motor symptoms. This review focuses on various aspects of PD, from clinical diagnosis to currently accepted treatment options, such as pharmacological management through dopamine replacement and surgical techniques such as deep brain stimulation (DBS).
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