Publications by authors named "K K Bal"
Background: Peyronie's disease (PD) is a progressive fibrotic disorder of the penis that can induce pain and erectile dysfunction and has various treatment modalities, including surgical, pharmaceutical, and injection therapies.
Methods: The authors used electronic medical records from Kaiser Permanente Southern California, an integrated health care system that consists of 15 medical centers, and identified patients diagnosed with stable PD without concomitant erectile dysfunction from January 1, 2004, to December 31, 2020. Baseline characteristics between surgical and injection groups were compared using Chi-squared and Kruskal-Wallis tests.
In this study, we investigated the effect of chitosan modification with tricine on transfection efficiency by preserving its ability to form complexes with plasmid DNA (pDNA) and increasing its hydrophilicity. The inherent limitations of chitosan, such as poor solubility at physiological pH, insufficient cellular uptake, and strong ionic interactions with pDNA, typically result in low transfection efficiency. To overcome these challenges, Tricine, a hydrophilic molecule containing a secondary amine group, was conjugated to chitosan.
View Article and Find Full Text PDFBackground: We planned this study considering that complications of deep neck infections can be seriously life threatening.
Aim: To raise awareness that introthoracic complications and necrotizing fasciitis are causes of serious mortality and morbidity.
Methods: This study was carried out with the participation of 188 patients who were treated at Mersin University Department of Otorhinolaryngology and Head and Neck Surgery at January 1, 2024.
Article Synopsis
- The study focuses on creating a new amphiphilic chitosan (Chi-MA) by combining myristic acid and tertiary amine groups for better gene delivery.
- The modified chitosan underwent thorough chemical characterization and was used to form nanoparticles, which were tested for their size, stability, and capabilities to deliver genes effectively.
- Results showed that Chi-MA significantly improved gene complexing (8-fold increase) and transfection efficiency without causing toxicity to HEK293T cells, highlighting it as an effective gene carrier.
Aneurysm of Petrous and Cavernous Parts of the Internal Carotid Artery: A Case Report.
Indian J Otolaryngol Head Neck Surg
August 2024
Article Synopsis
- Internal carotid artery (ICA) aneurysms, although rare, can lead to serious health issues like nerve compression and severe bleeding if they rupture.
- Symptoms often include neurologic signs, and detection may reveal pulsatile masses in the ear or nasal cavity.
- Diagnostic imaging, particularly cerebral digital subtraction angiography, is crucial before any surgical intervention, as demonstrated in a case study of a 48-year-old woman experiencing severe nosebleeds due to an ICA aneurysm.