Publications by authors named "K K Antony"
Introduction: Twin reversed arterial perfusion (TRAP) sequence is a rare complication of monochorionic twin pregnancies characterized by placental anastomoses between a normally developed twin and an acardiac mass. Though several treatment modalities exist, the optimal management strategy is unclear. This study aims to compare the various treatment strategies for TRAP sequence.
View Article and Find Full Text PDFBackground: Maternal periodontal disease is associated with preterm and low-birthweight deliveries, but randomized trials of likely efficacious treatments (e.g., dental scaling and root planing) during pregnancy have not reduced these adverse outcomes.
View Article and Find Full Text PDFCurrently, there are no placenta-targeted treatments to alter the in utero environment for administration to pregnant women who receive a diagnosis of fetal growth restriction (FGR). Water-soluble polymers have a distinguished record of clinical relevance outside of pregnancy. We have demonstrated the effective delivery of polymer-based nanoparticles containing a non-viral human insulin-like growth factor 1 (IGF1) transgene to correct placental insufficiency in small animal models of FGR.
View Article and Find Full Text PDFArticle Synopsis
- - Twin reversed arterial perfusion (TRAP) sequence is a serious condition that poses a high risk of mortality to one of the twins (the "pump twin") due to abnormal blood flow to the acardiac twin.
- - A case study involved a pregnant woman diagnosed with Stage IIb TRAP Sequence at 20 weeks, who successfully underwent a microwave ablation procedure to interrupt the blood supply to the acardiac mass at 21 weeks.
- - The procedure was effective, leading to the safe delivery of a healthy baby at 33 weeks and showcasing the potential benefits of using microwave ablation in managing TRAP sequence.
Background: Gestational diabetes mellitus affects up to 10% of pregnancies and is classified into subtypes gestational diabetes subtype A1 (GDMA1) (managed by lifestyle modifications) and gestational diabetes subtype A2 (GDMA2) (requiring medication). However, whether these subtypes are distinct clinical entities or more reflective of an extended spectrum of normal pregnancy endocrine physiology remains unclear.
Objective: Integrated bulk RNA-sequencing (RNA-seq), single-cell RNA-sequencing (scRNA-seq), and spatial transcriptomics harbors the potential to reveal disease gene signatures in subsets of cells and tissue microenvironments.