Publications by authors named "K Joehrens"
Background/aim: PD-L1 inhibitors have been approved for cisplatin-ineligible urothelial cancer patients relapsing after radical cystectomy. A prerequisite for therapy is a positive PD-L1 expression in the tumor tissue, whereas no options are available for patients with negative PD-L1 status. However, studies revealed that many PD-L1-negative patients also responded to PD-L1 therapy.
View Article and Find Full Text PDFMalignant transformation of oral lichen planus (OLP) into oral squamous cell carcinoma is considered as one of the most serious complications of OLP. For the early detection of oral cancer in OLP follow-up, accurate localization of the OLP center is still difficult but often required for confirmatory biopsy with histopathological examination. Optical coherence tomography (OCT) offers the potential for more reliable biopsy sampling in the oral cavity as it is capable of non-invasively imaging the degenerated oral layer structure.
View Article and Find Full Text PDFThis study presents a highly miniaturized, handheld probe developed for rapid assessment of soft tissue using optical coherencetomography (OCT). OCT is a non-invasive optical technology capable of visualizing the sub-surface structural changes that occur in soft tissue disease such as oral lichen planus. However, usage of OCT in the oral cavity has been limited, as the requirements for high-quality optical scanning have often resulted in probes that are heavy, unwieldy and clinically impractical.
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- Mature T cells in the bone marrow maintain homeostasis with the help of regulatory T cells (Tregs) and bone marrow-mesenchymal stem cells (BM-MSCs), but this balance is disrupted by BM transplantation (BMT), leading to issues with B-cell development.
- The study investigates the role of CD40, derived from radio-resistant cells in the host, in re-establishing the balance between T-effector (Teff) and Treg cells after BMT, using a murine model to assess T cell responses.
- Results indicate that lethal irradiation enhances CD40 and OX40L levels in BM-MSCs, where CD40 restrains OX40L, promoting Treg stability and improving B-cell
Most high-grade serous ovarian cancer (HGSOC) patients develop recurrent disease after first-line treatment, frequently with fatal outcome. This work aims at studying the molecular biology of both primary and recurrent HGSOC. Gene expression profiles of matched primary and recurrent fresh-frozen tumor tissues from 66 HGSOC patients were obtained by RNA sequencing.
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