Publications by authors named "K Jeppesen"
Background: Cellulitis is a common infection in Emergency Departments (EDs), and unclear diagnostics may lead to unnecessary treatment with broad-spectrum antibiotics. The aim of this study was to characterize patients with cellulitis admitted to the ED, describe the type and route of antibiotic treatment and compare the prognosis for cellulitis to that for other infections.
Methods: This multicenter, cross-sectional study prospectively included adult patients admitted to the ED suspected of having an infection.
Article Synopsis
- Acute kidney injury (AKI) significantly impacts long-term survival rates in patients who experience out-of-hospital cardiac arrest (OHCA), raising questions about its role as a primary risk factor versus a marker of initial condition severity.
- A study involving 759 comatose OHCA patients categorized them based on AKI severity using the KDIGO classification and assessed their survival rates over 365 days using adjusted Cox regression models.
- Results indicated that patients with AKI, whether requiring continuous kidney replacement therapy (CKRT) or not, had markedly lower survival rates compared to those without AKI, with similar hazard ratios indicating a consistent risk associated with both AKI groups.
Background: Cardiopulmonary bypass induces a systemic inflammatory response and alterations in fluid homeostasis, resulting in generalized tissue edema. Additionally, ischemia-reperfusion injury following cardioplegic arrest presumably prompts organ-specific myocardial edema.
Case Presentation: The case report presents a 75-year-old Caucasian male diagnosed with aortic dissection, Stanford type A, who underwent complicated open-heart surgery.
Treatment effects of blood pressure targets and hemodynamics according to initial blood lactate levels in comatose out-of-hospital cardiac arrest patients - A sub study of the BOX trial.
Resuscitation
January 2024
Background: Out-of-hospital cardiac arrest (OHCA) survivors remaining comatose are often circulatory unstable with high mortality in the first days following resuscitation. Elevated lactate will reflect the severity and duration of hypoperfusion in cardiac arrest. Further, the severity of hypoperfusion could modify the effect on survival of different mean arterial blood pressure (MAP) targets.
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- Acute kidney injury (AKI) is a serious concern following out-of-hospital cardiac arrest, and this study investigates how different blood pressure and oxygenation targets during post-resuscitation care affect AKI risk.
- The study involved 789 comatose adult patients and compared two blood pressure targets (63 vs. 77 mm Hg) and two oxygen targets (9-10 kPa vs. 13-14 kPa) to determine AKI incidence based on KDIGO criteria.
- Results showed that patients with low blood pressure and liberal oxygen target had a higher risk (44% vs. 30%) of developing mild-stage AKI, although plasma creatinine levels did not differ significantly at the 6- and 12