Publications by authors named "K Jalalvand"
Background: The study of Y-chromosomal variations provides valuable insights into male susceptibility in certain diseases like cardiovascular disease (CVD). In this study, we analyzed paternal lineage in different Iranian ethnic groups, not only to identify developing medical etiology, but also to pave the way for gender-specific targeted strategies and personalized medicine in medical genetic research studies.
Methods: The diversity of eleven Iranian ethnic groups was studied using 27 Y-chromosomal short tandem repeat (Y-STR) haplotypes from Y-filer® Plus kit.
Genetic analysis of non-syndromic hearing loss (NSHL) has been challenged due to marked clinical and genetic heterogeneity. Today, advanced next-generation sequencing (NGS) technologies, such as exome sequencing (ES), have drastically increased the efficacy of gene identification in heterogeneous Mendelian disorders. Here, we present the utility of ES and re-evaluate the phenotypic data for identifying candidate causal variants for previously unexplained progressive moderate to severe NSHL in an extended Iranian family.
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- Global real-time monitoring of SARS-CoV-2 variants is essential for controlling COVID-19, leading to the development of a Sanger-based platform for variant tracking in low-resource labs.
- The study utilized nested RT-PCR and Sanger sequencing on 1,028 samples, achieving high concordance with whole genome sequencing for mutation detection and lineage assignment.
- The new method is effective for tracking variants of concern like Delta and Alpha, making it a viable option for countries with limited resources to monitor SARS-CoV-2 variants efficiently.
Article Synopsis
- The study analyzed the genetic diversity of SARS-CoV-2 in Iran over one year, following two independent viral introductions during the early outbreak phase.
- Researchers sequenced 319 whole genomes between March 2020 and May 2021 to monitor the circulating viral lineages.
- Results showed that different SARS-CoV-2 clades dominated various waves of infection, with the Delta variant emerging as a crucial factor in the fifth wave, highlighting significant mutations in key lineages.
The SARS-CoV-2 virus has been rapidly spreading globally since December 2019, triggering a pandemic, soon after its emergence. While Iran was among the first countries confronted with rapid spread of virus in February 2020, no real-time SARS-CoV-2 whole-genome tracking in early phase of outbreak was performed in the country. To address this issue, we provided 50 whole-genome sequences of viral isolates ascertained from different geographical locations in Iran during March-July 2020.
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