Endangered Przewalski's Horse, , Cloned from Historically Cryopreserved Cells.

Cloning from historically cryopreserved cells offers a potential means to restore lost genetic variation or increase the representation of particular lineages within bottlenecked species, provided such biobanked materials are archived for such genetic rescue applications. One species for which cloning can provide genetic management benefits is Przewalski's horse, . All ~1800 living Przewalski's horses, distributed across ex situ breeding facilities and in situ reintroduction sites, are descended from one or more of the five founder lineages established by the 12 horses captured from the wild between 1898 and 1947.

Psychometric properties of the Federal Unit Scale for general psychopathology screening without iatrogenic effects.

Mental health assessment tools play a crucial role in clinical practice, yet many existing scales risk exacerbating the conditions they aim to measure. This study introduces the Federal Unit Scale (FUS), a novel 5-item scale designed to assess a broad range of affect and traits capturing distress tolerance while minimizing potentially triggering language. The FUS was developed with a focus on combat veterans, frontline workers, and first responders.

Value of hospital administrative data linked to national cancer registry records to identify metastatic disease at time of primary diagnosis in colorectal cancer patients: a study using national data in England.

Background: Routinely collected data are increasingly being used for cancer research and health service evaluation. For both purposes, accurately identifying metastatic disease at diagnosis is essential. We developed an approach to identify metastatic disease at time of primary diagnosis according to national hospital administrative data (HAD) in patients identified with colorectal cancer (CRC) in the English national cancer registry (CR).

Atosiban versus placebo for threatened preterm birth (APOSTEL 8): a multicentre, randomised controlled trial.

Background: Tocolytics are recommended in international guidelines as treatment for threatened preterm birth. Atosiban, an oxytocin receptor antagonist, is a registered tocolytic drug specifically indicated for the treatment of threatened preterm birth. Although tocolytics have been shown to delay birth, benefits on neonatal outcomes have not been demonstrated.

Towards improved measurements of bone conduction auditory brainstem responses in infants and adults: mitigation of stimulus artefact.

Objective: To reduce the amplitude of stimulus artefacts present in bone conduction auditory brainstem response (BC ABR) measurements.

Design: Electromagnetic shielding was applied to the surface of a clinical BC transducer. A foam pad was also placed on the shielded mastoid-contacting plate of the transducer.