Publications by authors named "K J Siebert"
Article Synopsis
- Exclusive enteral nutrition (EEN) is a crucial treatment for pediatric Crohn's disease, but the exact protective mechanisms of how it works are not fully understood.
- A research study analyzed the fecal microbiota and metabolites in treatment-naive Crohn’s patients, identifying key protective features like Lachnospiraceae and medium-chain fatty acids.
- The findings demonstrated that EEN leads to distinct changes in gut microbiome compositions that vary by individual, potentially influencing the development or prevention of inflammatory bowel disease through these microbiome dynamics.
Article Synopsis
- Pediatric patients with eosinophilic esophagitis (EoE) can experience ongoing inflammation and symptoms even after histologic improvement, indicating deeper molecular issues.
- A study involving 247 esophageal biopsy samples identified persistent molecular changes in EoE, including 17 dysregulated genes and 6 proteins that remained altered even in inactive stages of the disease.
- The findings reveal that while some molecular markers normalize in deep remission, others, particularly periostin (POSTN), continue to be elevated, indicating a need for further understanding of EoE's molecular landscape for better treatment strategies.
Article Synopsis
- The bacteria called (the name is missing) causes a common kind of lung infection known as pneumonia around the world.
- Researchers found that this bacteria can break down important proteins in the lung that help keep it strong and healthy.
- They discovered that when the bacteria changes the acid levels in the lungs, it makes things worse, but if they keep the acid levels normal, it helps protect the lungs and immune system during the infection.
Article Synopsis
- This case report discusses a rare condition called exogenous lipoid pneumonia (ELP), which happens when lipid substances are inhaled, leading to inflammation in the lungs.
- The patient was an 83-year-old woman who used paraffin oil as a mouthwash over a long period, which contributed to her condition.
- Diagnosis of ELP was confirmed through her medical history, specific imaging results, and tissue analysis.
To study individual recognition in animals, discrimination tasks are often conducted by presenting 2D images of real conspecifics. However, animals may discriminate the images merely as visual stimulus combinations without establishing referential relationships to the individuals depicted. In the current study, we investigated whether goats are able to discriminate photos of familiar and unfamiliar conspecifics, whether they not only process the photos as visual stimuli, but also understand them as virtual copies of real conspecifics and whether they grasp the concept of familiarity.
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