Publications by authors named "K J Seung"
Background: The 2022 WHO guidelines on multi-drug/rifampicin resistant tuberculosis (MDR/RR-TB) recommend six months of bedaquiline (Bdq) in the all-oral 9-month shorter regimen and six months or longer for Bdq and delamanid (Dlm) in the 18-20-month longer regimen. However, lack of evidence on extended treatment using Bdq or Dlm has limited their use to six months. We examine the frequency and incidence of QT prolongation based on duration of Bdq and/or Dlm use in longer regimens.
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- Gas bubbles form during water electrolysis, where hydrogen and oxygen are generated, and they affect the electrode's performance by decreasing its active area.
- The study uses grazing incidence small-angle X-ray scattering (GISAXS) and optical microscopy to track how the size and coverage of nanobubbles evolve over time during the electrolysis process.
- It finds that as more charge is passed, the number of nanobubbles increases while their size decreases, and it suggests that reducing dissolved hydrogen could help minimize nanobubble coverage on the surface.
Article Synopsis
- - The long-term effects of tuberculosis (TB), particularly post-tuberculosis lung disease (PTLD), are a major global health issue, affecting over half of patients after TB treatment, yet it's largely ignored in policies.
- - There is a critical need for clear guidelines on diagnosing and managing PTLD, which should include mandatory screening for all individuals finishing TB therapy and ensuring they have access to necessary chronic care resources.
- - Major funding organizations like The Global Fund are encouraged to incorporate PTLD into their strategies to improve care, emphasizing the importance of addressing long-term complications of TB beyond just the initial treatment.
Background: In 2019, the World Health Organization called for operational research on all-oral shortened regimens for multidrug- and rifampicin-resistant tuberculosis (MDR/RR-TB). We report safety and effectiveness of three 9-month all-oral regimens containing bedaquiline (Bdq), linezolid (Lzd), and levofloxacin (Lfx) and reinforced with cycloserine (Cs) and clofazimine (Cfz), delamanid (Dlm) and pyrazinamide (Z), or Dlm and Cfz.
Methods: We conducted a prospective cohort study of patients initiating treatment for pulmonary MDR/RR-TB under operational research conditions at public health facilities in Kazakhstan.
Sputum culture reversion after conversion is an indicator of tuberculosis (TB) treatment failure. We analyze data from the endTB multi-country prospective observational cohort (NCT03259269) to estimate the frequency (primary endpoint) among individuals receiving a longer (18-to-20 month) regimen for multidrug- or rifampicin-resistant (MDR/RR) TB who experienced culture conversion. We also conduct Cox proportional hazard regression analyses to identify factors associated with reversion, including comorbidities, previous treatment, cavitary disease at conversion, low body mass index (BMI) at conversion, time to conversion, and number of likely-effective drugs.
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