Publications by authors named "K J Sears"
Purpose: To describe a case series of presumed Sympathetic Ophthalmia (SO) triggered by diode laser cyclophotocoagulation (CPC) for the treatment of neovascular glaucoma.
Methods: Patients developing bilateral granulomatous uveitis after CPC between 2014 and 2024. Cases with prior ocular trauma or penetrating ocular surgery were excluded.
This study examined the effects of blood flow restriction (BFR) on motor unit (MU) behaviour of the biceps brachii (BB) during a single non-exhausting submaximal muscle action. Twenty adults performed maximal voluntary contractions (MVCs) of the elbow flexors, followed by an isometric trapezoidal muscle action at 40% MVC during BFR and control (CON) visits. Surface electromyographic signals recorded from the BB during the 40% MVCs were decomposed.
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- - Medical exome sequencing involves multiple steps to identify and prioritize genetic variants before interpretation by professionals, ultimately aiming to provide meaningful reports to patients.
- - A study examined over 13,000 curated variants from 289 patients, identifying 278 clinically significant SNPs and a large number of technical artifacts, with variant allele frequencies (VAFs) playing a crucial role in filtering.
- - The research suggests that excluding SNPs with a VAF below 0.30 could streamline the curation process by about 20% without missing important medical variants.
Article Synopsis
- Bats are increasingly recognized as valuable models for aging research due to their long lifespan, living over 20 to 40 years in the wild or captivity.
- Their unique biological traits, such as resistance to viral infections and efficient DNA repair mechanisms, offer insights that could enhance healthy aging in humans.
- The review discusses eight specific areas where bat research can inform our understanding of aging, including genetics, immunity, neurobiology, and even aspects related to menopause, making bats potentially more relevant to human aging studies than traditional lab animals like rodents.